Arsenic cancer risk confounder in Southwest Taiwan data set

Steven H. Lamm, Arnold Engel, Cecilia A. Penn, Rusan Chen, Manning Feinleib

Research output: Contribution to journalArticle

Abstract

Quantitative analysis for the risk of human cancer from the ingestion of inorganic arsenic has been based on the reported cancer mortality experience in the blackfoot disease (BFD)-endemic area of southwest Taiwan. Linear regression analysis shows that arsenic as the sole etiologic factor accounts for only 21% of the variance in the village standardized mortality ratios for bladder and lung cancer. A previous study had reported the influence of confounders (township, BFD prevalence, and artesian well dependency) qualitatively, but they have not been introduced into a quantitative assessment. In this six-township study, only three townships (2, 4, and 6) showed a significant positive dose-response relationship with arsenic exposure. The other three townships (0, 3, and 5) demonstrated significant bladder and lung cancer risks that were independent of arsenic exposure. The data for bladder and lung cancer mortality for townships 2, 4, and 6 fit an inverse linear regression model (p <0.001) with an estimated threshold at 151 μg/L (95% confidence interval, 42 to 229 μg/L). Such a model is consistent with epidemiologic and toxicologic literature for bladder cancer. Exploration of the southwest Taiwan cancer mortality data set has clarified the dose-response relationship with arsenic exposure by separating out township as a confounding factor.

Original languageEnglish (US)
Pages (from-to)1077-1082
Number of pages6
JournalEnvironmental Health Perspectives
Volume114
Issue number7
DOIs
StatePublished - Jul 2006

Fingerprint

Arsenic
Taiwan
arsenic
cancer
Urinary Bladder Neoplasms
Linear Models
Lung Neoplasms
Mortality
mortality
Neoplasms
Linear regression
dose-response relationship
Water Wells
Endemic Diseases
artesian well
disease prevalence
Regression analysis
confidence interval
quantitative analysis
Eating

Keywords

  • Arsenic
  • Blackfoot disease
  • Bladder cancer
  • Cancer risk
  • Confounder
  • Dose-response relationship
  • Southwest Taiwan
  • Threshold model

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Lamm, S. H., Engel, A., Penn, C. A., Chen, R., & Feinleib, M. (2006). Arsenic cancer risk confounder in Southwest Taiwan data set. Environmental Health Perspectives, 114(7), 1077-1082. https://doi.org/10.1289/ehp.8704

Arsenic cancer risk confounder in Southwest Taiwan data set. / Lamm, Steven H.; Engel, Arnold; Penn, Cecilia A.; Chen, Rusan; Feinleib, Manning.

In: Environmental Health Perspectives, Vol. 114, No. 7, 07.2006, p. 1077-1082.

Research output: Contribution to journalArticle

Lamm, SH, Engel, A, Penn, CA, Chen, R & Feinleib, M 2006, 'Arsenic cancer risk confounder in Southwest Taiwan data set', Environmental Health Perspectives, vol. 114, no. 7, pp. 1077-1082. https://doi.org/10.1289/ehp.8704
Lamm, Steven H. ; Engel, Arnold ; Penn, Cecilia A. ; Chen, Rusan ; Feinleib, Manning. / Arsenic cancer risk confounder in Southwest Taiwan data set. In: Environmental Health Perspectives. 2006 ; Vol. 114, No. 7. pp. 1077-1082.
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