Arrhenoblastoma of the ovary. Presentation of a case report and a discussion of the differential diagnosis

H. Melvin Radman, Belur S. Bhagavan

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A study has been presented of a 15-year-old girl who had an arrhenoblastoma of the right ovary. The clinical signs and symptoms included a secondary amenorrhea, hirsutism, acneform eruption, hoarseness of voice, loss of breast development, clitoromegaly, and a right adnexal mass. The laboratory findings revealed an elevation of the total and fractionated elements of the urinary 17-ketosteroids. Excellent suppression was obtained with the use of dexamethasone. Despite continued cortisone therapy, a gradual rise occurred in the fractionated levels of the 17-ketosteroids. In turn, such entities as adrenal hyperplasia, genetic abnormality, and Cushing's syndrome were eliminated as possible diagnoses. The removal of the adnexal mass, which proved to be an arrhenoblastoma, resulted in the return of regular menses and some loss of hirsutism. The fractionated and total urinary 17-ketosteroid values fell and remained at normal levels. The efficacy of fractionation of the urinary 17-ketosteroids and the cortisone suppression tests in the investigation of the hirsute woman is emphasized.

Original languageEnglish (US)
Pages (from-to)1187-1190
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Issue number8
StatePublished - Apr 15 1970

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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