Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

Murali D. Bashyam, Ryan Bair, Young H. Kim, Pei Wang, Tina Hernandez-Boussard, Collins A. Karikari, Robert Tibshirani, Anirban Maitra, Jonathan R. Pollack

Research output: Contribution to journalArticlepeer-review

Abstract

Pancreatic cancer, the fourth leading cause of cancer death in the United States, is frequently associated with the amplification and deletion of specific oncogenes and tumor-suppressor genes (TSGs), respectively. To identify such novel alterations and to discover the underlying genes, we performed comparative genomic hybridization on a set of 22 human pancreatic cancer cell lines, using cDNA microarrays measuring ∼26,000 human genes (thereby providing an average mapping resolution of

Original languageEnglish (US)
Pages (from-to)556-562
Number of pages7
JournalNeoplasia
Volume7
Issue number6
DOIs
StatePublished - Jun 2005

Keywords

  • Array CGH
  • Comparative genomic hybridization
  • DNA amplification
  • Expression profiling
  • Pancreatic cancer

ASJC Scopus subject areas

  • Cancer Research

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