Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

Murali D. Bashyam, Ryan Bair, Young H. Kim, Pei Wang, Tina Hernandez-Boussard, Collins A. Karikari, Robert Tibshirani, Anirban Maitra, Jonathan R. Pollack

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

Pancreatic cancer, the fourth leading cause of cancer death in the United States, is frequently associated with the amplification and deletion of specific oncogenes and tumor-suppressor genes (TSGs), respectively. To identify such novel alterations and to discover the underlying genes, we performed comparative genomic hybridization on a set of 22 human pancreatic cancer cell lines, using cDNA microarrays measuring ∼26,000 human genes (thereby providing an average mapping resolution of

Original languageEnglish (US)
Pages (from-to)556-562
Number of pages7
JournalNeoplasia
Volume7
Issue number6
DOIs
StatePublished - Jun 2005

Keywords

  • Array CGH
  • Comparative genomic hybridization
  • DNA amplification
  • Expression profiling
  • Pancreatic cancer

ASJC Scopus subject areas

  • Cancer Research

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