Aromatase inhibitor treatment of menorrhagia and subsequent pregnancy in a patient with familial hyperparathyroidism-jaw tumor syndrome

Erin F. Wolff, Micah J. Hill, William F. Simonds, James H. Segars

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To describe the clinical management of menorrhagia in a woman with hyperparathyroidism-jaw tumor syndrome (HPT-JT). Design: Case report. Setting: Large translation research hospital. Patient(s): A 26-year-old nulligravid woman with familial HPT-JT presented with life-long menorrhagia resistant to progesterone intrauterine device (IUD) therapy and a desire for fertility. Intervention(s): Aromatase inhibitor therapy. Main Outcome Measure(s): Clinical response to therapy and pregnancy. Result(s): Imaging demonstrated an enlarged endometrial lining and thickening of the junctional zone. At operative hysteroscopy, multiple atypical endometrial polyp-like lesions filled the entire uterine cavity and were removed. Histologic evaluation demonstrated the lesions to be adenomyomas with an abundance of aromatase expression. Postoperative treatment included an aromatase inhibitor. The patient's menorrhagia, which had previously been resistant to progesterone IUD therapy, resolved with the aromatase inhibitor. After 10 months of this treatment, the aromatase inhibitor was discontinued and a repeated hysteroscopy revealed a markedly improved uterine cavity. The patient subsequently became pregnant on her first natural cycle and delivered a healthy term infant. Conclusion(s): Aromatase inhibitors may represent a novel treatment for benign uterine pathology in HPT-JT.

Original languageEnglish (US)
Pages (from-to)1616-1619
Number of pages4
JournalFertility and sterility
Volume98
Issue number6
DOIs
StatePublished - Dec 2012
Externally publishedYes

Keywords

  • Hyperparathyroidism-jaw tumor syndrome
  • adenomyoma
  • aromatase inhibitor
  • menorrhagia

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Aromatase inhibitor treatment of menorrhagia and subsequent pregnancy in a patient with familial hyperparathyroidism-jaw tumor syndrome'. Together they form a unique fingerprint.

Cite this