@article{ea0a25f0db4b4375a8e17aeae20c236d,
title = "Arm paralysis after routine childhood vaccinations: Application of advanced molecular methods to the causality assessment of an adverse event after immunization",
abstract = "Post-licensure surveillance for adverse events following immunizations (AEFI) can identify rare complications of vaccinations and rigorous vaccine adverse event causality assessments can help to identify possible causal relationships. We report the development of arm paralysis after varicella vaccination in a 1-year-old child. Paralysis was initially presumed to be due to vOka because of the temporal relationship between vaccination and onset of arm weakness; however, molecular studies identified wild-type varicella zoster virus VZV (WT-VZV) in the CSF, leading the authors to conclude that WT-VZV was the probable cause. This case illustrates the complexity of assessing AEFI causality, and the importance of careful and complete evaluations when determining the most likely cause of an AEFI.",
keywords = "Adverse event after vaccination, Child, Paralysis, Vaccine, Varicella-zoster virus",
author = "Jana Shaw and Halsey, {Neal A.} and Adriana Weinberg and {Scott Schmid}, D. and George, {Kirsten St} and Weldon, {William C.} and Michael Jordan and Bryant, {Patrick W.} and LaRussa, {Philip S.} and Bradshaw, {Deborah Y.} and Theresa Harrington and Anne Gershon",
note = "Funding Information: 1Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University, Golisano Children{\textquoteright}s Hospital, Syracuse; 2Institute for Vaccine Safety, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; 3Departments of Pediatrics, Medicine and Pathology, Director, Molecular and Virology Clinical Laboratories, University of Colorado Denver, Aurora; 4National Center for Immunizations and Respiratory Diseases, Division of Viral Diseases, Atlanta, Georgia; 5Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Clinical Professor, Department of Biomedical Sciences, University at Albany, SUNY; 6Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; 7Pediatrics, Divisions of Immunobiology, and Bone Marrow Transplantation and Immune Deficiency Cincinnati Children{\textquoteright}s Hospital/University of Cincinnati, Ohio; 8Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany; 9Department of Pediatrics, Division of Pediatric Infectious Diseases, Columbia University, New York, New York; 10Department of Neurology, Upstate Medical University, New York, New York; 11Centers for Disease Control and Prevention, National Center for Emerging, Zoonotic, and Infectious Diseases, Division of Healthcare Quality Promotion, Immunization Safety Office, Clinical Immunization Safety Assessment Project, Atlanta, Georgia; 12Columbia University College of Physicians and Surgeons, New York, New York Publisher Copyright: {\textcopyright} The Author 2017. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved.",
year = "2017",
month = sep,
day = "1",
doi = "10.1093/jpids/piw084",
language = "English (US)",
volume = "6",
pages = "e161--e164",
journal = "Journal of the Pediatric Infectious Diseases Society",
issn = "2048-7193",
publisher = "Oxford University Press",
number = "3",
}