Aripiprazole for cocaine abstinence: A randomized-controlled trial with ecological momentary assessment

Landhing M. Moran, Karran A. Phillips, William J. Kowalczyk, Udi E. Ghitza, Daniel A. Agage, David H. Epstein, Kenzie L. Preston

Research output: Contribution to journalArticlepeer-review

Abstract

Aripiprazole blocks psychostimulant seeking in a rat model of relapse. However, in humans, it may increase ongoing use. We tested aripiprazole specifically for relapse prevention. Methadone-maintained outpatients who were abstinent from cocaine in weeks 11-12 were randomized to double-blind aripiprazole (15mg daily) or placebo in weeks 13-27 after 12 weeks of contingency management. Participants reported craving through ecological momentary assessment. We stopped the trial because very few (18/41) participants fulfilled the abstinence criterion. The results suggested that aripiprazole delayed lapse [hazard ratio (HR)=0.45, 95% confidence interval (CI)=0.14-1.42, P=0.17] and relapse (HR=0.31, 95% CI=0.07-1.27, P=0.10), but the effects did not reach statistical significance. Unexpectedly, the proportion of participants reporting cocaine craving was higher in the aripiprazole group (Fisher's exact P=0.026), although the frequency of craving was similar in the aripiprazole and placebo groups (1.89 vs. 1.16%, reffect=0.43, 95% CI=-0.08-0.76). The results suggest that in recently abstinent cocaine users, aripiprazole might delay relapse, but might also slightly increase craving. Difficulty in trial implementation underscores the fact that initial abstinence from cocaine is not a trivial hurdle.

Original languageEnglish (US)
Pages (from-to)63-73
Number of pages11
JournalBehavioural Pharmacology
Volume28
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • Cocaine
  • D2 partial agonists
  • Ecological momentary assessment
  • Human
  • Relapse prevention

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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