Arginase and vascular aging

Lakshmi Santhanam, David W. Christianson, Daniel Nyhan, Dan E Berkowitz

Research output: Contribution to journalArticle

Abstract

Vascular and associated ventricular stiffness is one of the hallmarks of the aging cardiovascular system. Both an increase in reactive oxygen species production and a decrease in nitric oxide (NO) bioavailability contribute to the endothelial dysfunction that underlies this vascular stiffness, independent of other age-related vascular pathologies such as atherosclerosis. The activation/upregulation of arginase appears to be an important contributor to age-related endothelial dysfunction by a mechanism that involves substrate (L-arginine) limitation for NO synthase (NOS) 3 and therefore NO synthesis. Not only does this lead to impaired NO production but also it contributes to the enhanced production of reactive oxygen species by NOS. Although arginase abundance is increased in vascular aging models, it appears that posttranslational modification by S-nitrosylation of the enzyme enhances its activity as well. The S-nitrosylation is mediated by the induction of NOS2 in the endothelium. Furthermore, arginase activation contributes to aging-related vascular changes by mechanisms that are not directly related to changes in NO signaling, including polyamine-dependent vascular smooth muscle proliferation and collagen synthesis. Taken together, arginase may represent an as yet elusive target for the modification of age-related vascular and ventricular stiffness contributing to cardiovascular morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)1632-1642
Number of pages11
JournalJournal of Applied Physiology
Volume105
Issue number5
DOIs
StatePublished - Nov 2008

Fingerprint

Arginase
Blood Vessels
Nitric Oxide
Vascular Stiffness
Nitric Oxide Synthase
Reactive Oxygen Species
Polyamines
Post Translational Protein Processing
Cardiovascular System
Vascular Smooth Muscle
Biological Availability
Endothelium
Arginine
Atherosclerosis
Up-Regulation
Collagen
Pathology
Morbidity
Mortality
Enzymes

Keywords

  • L-arginine pools
  • Nitric oxide synthase 3
  • Nitric oxide synthase uncoupling
  • S-nitrosylation
  • Vascular stiffness

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Arginase and vascular aging. / Santhanam, Lakshmi; Christianson, David W.; Nyhan, Daniel; Berkowitz, Dan E.

In: Journal of Applied Physiology, Vol. 105, No. 5, 11.2008, p. 1632-1642.

Research output: Contribution to journalArticle

Santhanam, Lakshmi ; Christianson, David W. ; Nyhan, Daniel ; Berkowitz, Dan E. / Arginase and vascular aging. In: Journal of Applied Physiology. 2008 ; Vol. 105, No. 5. pp. 1632-1642.
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