Arginase-1 is frequently positive in hepatoid adenocarcinomas

Vishal S. Chandan, Sejal S. Shah, Michael S. Torbenson, Tsung Teh Wu

Research output: Contribution to journalArticle

Abstract

Summary Hepatoid adenocarcinoma is a rare extrahepatic tumor, which shows morphological and immunohistochemical similarities to hepatocellular carcinoma (HCC). Hence, hepatoid adenocarcinoma can cause diagnostic confusion with HCC. Arginase-1 immunostain has been recently shown to be an excellent marker of normal hepatocytes and is a sensitive and specific marker for HCC. However, the expression of Arginase-1 in hepatoid adenocarcinoma has not been evaluated in detail. Eight cases of hepatoid adenocarcinoma were immunostained with Arginase-1, Hepar-1, Glypican-3, CK7, CK20, CK19, polyclonal carcinoembryonic antigen, α-fetoprotein, CDX2, and TTF-1. Albumin in situ hybridization was performed in 4 cases. All 8 cases were positive for Hepar-1. Arginase-1 was positive in 5 (62.5%) of 8 cases; 2 of these cases showed diffuse staining, while 3 showed patchy staining. Glypican-3, CK7 and α-fetoprotein were each positive in 4 (50%) of 8 cases. CK19 was positive in 3 (37.5%) of 8 cases. polyclonal carcinoembryonic antigen showed canalicular staining in 3 (37.5%) of 8 cases and albumin in situ hybridization was positive in 3 (75%) of 4 cases. CDX2 was positive in 2 (25%) of 8 cases, both arising from the stomach. CK20 was positive in 1 (12.5%) of 8 case while TTF-1 was negative in all cases. Hepatoid adenocarcinoma has a similar immunostaining profile as HCC. Arginase-1 expression is common (62.5%) in hepatoid adenocarcinoma and hence it is not useful in distinguishing HCC from hepatoid adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalHuman Pathology
Volume55
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Fingerprint

Arginase
Adenocarcinoma
Hepatocellular Carcinoma
Glypicans
Fetal Proteins
Carcinoembryonic Antigen
Staining and Labeling
In Situ Hybridization
Albumins
Hepatocytes
Stomach

Keywords

  • Arginase-1
  • Glypican-3
  • Hepar-1
  • Hepatocellular carcinoma
  • Hepatoid adenocarcinoma
  • α-Fetoprotein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Chandan, V. S., Shah, S. S., Torbenson, M. S., & Wu, T. T. (2016). Arginase-1 is frequently positive in hepatoid adenocarcinomas. Human Pathology, 55, 11-16. https://doi.org/10.1016/j.humpath.2016.04.008

Arginase-1 is frequently positive in hepatoid adenocarcinomas. / Chandan, Vishal S.; Shah, Sejal S.; Torbenson, Michael S.; Wu, Tsung Teh.

In: Human Pathology, Vol. 55, 01.09.2016, p. 11-16.

Research output: Contribution to journalArticle

Chandan, Vishal S. ; Shah, Sejal S. ; Torbenson, Michael S. ; Wu, Tsung Teh. / Arginase-1 is frequently positive in hepatoid adenocarcinomas. In: Human Pathology. 2016 ; Vol. 55. pp. 11-16.
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AB - Summary Hepatoid adenocarcinoma is a rare extrahepatic tumor, which shows morphological and immunohistochemical similarities to hepatocellular carcinoma (HCC). Hence, hepatoid adenocarcinoma can cause diagnostic confusion with HCC. Arginase-1 immunostain has been recently shown to be an excellent marker of normal hepatocytes and is a sensitive and specific marker for HCC. However, the expression of Arginase-1 in hepatoid adenocarcinoma has not been evaluated in detail. Eight cases of hepatoid adenocarcinoma were immunostained with Arginase-1, Hepar-1, Glypican-3, CK7, CK20, CK19, polyclonal carcinoembryonic antigen, α-fetoprotein, CDX2, and TTF-1. Albumin in situ hybridization was performed in 4 cases. All 8 cases were positive for Hepar-1. Arginase-1 was positive in 5 (62.5%) of 8 cases; 2 of these cases showed diffuse staining, while 3 showed patchy staining. Glypican-3, CK7 and α-fetoprotein were each positive in 4 (50%) of 8 cases. CK19 was positive in 3 (37.5%) of 8 cases. polyclonal carcinoembryonic antigen showed canalicular staining in 3 (37.5%) of 8 cases and albumin in situ hybridization was positive in 3 (75%) of 4 cases. CDX2 was positive in 2 (25%) of 8 cases, both arising from the stomach. CK20 was positive in 1 (12.5%) of 8 case while TTF-1 was negative in all cases. Hepatoid adenocarcinoma has a similar immunostaining profile as HCC. Arginase-1 expression is common (62.5%) in hepatoid adenocarcinoma and hence it is not useful in distinguishing HCC from hepatoid adenocarcinoma.

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