Area postrema neurons are modulated by the adipocyte hormone adiponectin

Mark Fry, Pauline M. Smith, Ted D. Hoyda, Marnie Duncan, Rexford S. Ahima, Keith A. Sharkey, Alastair V. Ferguson

Research output: Contribution to journalArticlepeer-review


Adiponectin is an adipocyte-derived peptide hormone involved in energy homeostasis and the pathogenesis of obesity, including hypertension. Area postrema (AP) lacks a blood-brain barrier and is a critical homeostatic integration center for humoral and neural signals. Here we investigate the role of AP in adiponectin signaling. We show that rat AP expresses AdipoR1 and AdipoR2 adiponectin receptor mRNA. We used current-clamp electrophysiology to investigate whether adiponectin influenced membrane properties of AP neurons and found that ∼60% of rat AP neurons tested were sensitive to adiponectin. Additional electrophysiology experiments coupled with single-cell reverse transcription-PCR indicated that all neurons that expressed both subtypes of receptor were sensitive to adiponectin, whereas neurons expressing only one subtype were predominantly insensitive. Last, microinjection of adiponectin into AP caused significant increases in arterial blood pressure, with no change in heart rate, suggesting that adiponectin acts at AP to provide a possible link between control of energy homeostasis and cardiovascular function.

Original languageEnglish (US)
Pages (from-to)9695-9702
Number of pages8
JournalJournal of Neuroscience
Issue number38
StatePublished - Sep 20 2006
Externally publishedYes


  • Adiponectin
  • Area postrema
  • Circumventricular organ
  • Homeostasis
  • Microinjection
  • Patch clamp

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Area postrema neurons are modulated by the adipocyte hormone adiponectin'. Together they form a unique fingerprint.

Cite this