Area postrema and adjacent nucleus of the solitary tract in water and sodium balance

T. M. Hyde, R. R. Miselis

Research output: Contribution to journalArticlepeer-review

Abstract

Lesions of the area postrema (AP) and adjacent caudal medial nucleus of the solitary tract (cmNTS) cause significant changes in water and sodium balance. Lesioned rats display a permanent polydipsia, which in part is due to a primary polyuria. Water-to-food ratios are elevated chronically. Lesioned rats are unable to concentrate their urine as well as controls. In addition, lesioned rats overdrink in response to 24-h water deprivation. This lesion also causes a natriuresis and an overconsumption of 3% NaCl solution. These findings establish the AP-cmNTS as an important part of the neurocircuitry underlying water and sodium balance.

Original languageEnglish (US)
Pages (from-to)R173-R182
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume16
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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