TY - JOUR
T1 - Area and volume measurement of posterior fossa structures in MRI
AU - Aylward, Elizabeth H.
AU - Reiss, Allan
N1 - Funding Information:
Acknowledgements--This research was supported by grant 5T 32 GOd 149, Research Training in the Dementias of Aging, from the National Institute on Aging, by grant MH00726 from the National Institute of Mental Health, grant kiD 24061 and a Biomedical Research Support Grant from the National Institutes of Health, and a grant from the John Merck Fund (Dr. Reiss).
PY - 1991
Y1 - 1991
N2 - This study was undertaken to determine the extent to which area measures of posterior fossa structures can be used confidently to represent structure volumes. MRI scans were obtained from three groups: fragile X males, males with other developmental disabilities, and males with normal IQ. The areas of the midbrain, pons, medulla, cerebellar vermis, and fourth ventricle were measured in midsagittal sections. Volumes of midbrain, pons, medulla, cerebellum, fourth ventricle, and third ventricle were obtained by measuring these structures in contiguous axial slices. In addition, the largest axial area for each structure was identified. Analysis revealed that midsagittal area measures for pons, medulla, and fourth ventricle were significantly correlated with structure volumes, and that all of the largest axial area measures were significantly correlated with structure volumes. However, only the midsagittal area measure of fourth ventricle and the largest axial area measures of fourth ventricle and cerebellum were correlated with volume measures with an r of .80 of greater. Results of this study suggest that area measures may not accurately represent three-dimensional structure size.
AB - This study was undertaken to determine the extent to which area measures of posterior fossa structures can be used confidently to represent structure volumes. MRI scans were obtained from three groups: fragile X males, males with other developmental disabilities, and males with normal IQ. The areas of the midbrain, pons, medulla, cerebellar vermis, and fourth ventricle were measured in midsagittal sections. Volumes of midbrain, pons, medulla, cerebellum, fourth ventricle, and third ventricle were obtained by measuring these structures in contiguous axial slices. In addition, the largest axial area for each structure was identified. Analysis revealed that midsagittal area measures for pons, medulla, and fourth ventricle were significantly correlated with structure volumes, and that all of the largest axial area measures were significantly correlated with structure volumes. However, only the midsagittal area measure of fourth ventricle and the largest axial area measures of fourth ventricle and cerebellum were correlated with volume measures with an r of .80 of greater. Results of this study suggest that area measures may not accurately represent three-dimensional structure size.
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U2 - 10.1016/0022-3956(91)90020-B
DO - 10.1016/0022-3956(91)90020-B
M3 - Article
C2 - 1723429
AN - SCOPUS:0026068116
SN - 0022-3956
VL - 25
SP - 159
EP - 168
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 4
ER -