Are we waking up to the effects of NEFA?

Research output: Contribution to journalArticle

Abstract

NEFA are mobilised from adipose tissues during fasting or stress. Under conditions of acute or chronic NEFA excess, skeletal muscle and hepatic insulin resistance may ensue. Hence, a wealth of literature has focused on the crosstalk between NEFA and glucose in the pathogenesis of insulin resistance. Sleep restriction has also been shown to acutely induce insulin resistance, and self-reported short sleep duration is associated with diabetes. In this issue of Diabetologia (DOI: 10.1007/s00125-015-3500-4), Broussard and colleagues examine the impact of acute sleep restriction on detailed 24 h metabolic profiles, including plasma NEFA. Here, we address the potential clinical relevance of these findings and pose questions for further research.

Original languageEnglish (US)
Pages (from-to)651-653
Number of pages3
JournalDiabetologia
Volume58
Issue number4
DOIs
StatePublished - 2015

Fingerprint

Nonesterified Fatty Acids
Insulin Resistance
Sleep
Metabolome
Adipose Tissue
Fasting
Skeletal Muscle
Glucose
Liver
Research

Keywords

  • Diabetes
  • Fatty acids
  • NEFA
  • Sleep restriction

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Are we waking up to the effects of NEFA? / Jun, Jonathan; Polotsky, Vsevolod.

In: Diabetologia, Vol. 58, No. 4, 2015, p. 651-653.

Research output: Contribution to journalArticle

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