TY - JOUR
T1 - Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies?
AU - Batcheller, April
AU - Cardozo, Eden
AU - Maguire, Marcy
AU - DeCherney, Alan H.
AU - Segars, James H.
N1 - Funding Information:
Supported by research grant Z01-HD-008737-09 , Intramural Research Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Development, National Institutes of Health .
PY - 2011/12
Y1 - 2011/12
N2 - Objective: To review recent data regarding subtle, but widespread, epigenetic alterations in phenotypically normal offspring conceived by assisted reproductive technologies (ART) compared with offspring conceived in vivo. Design: A PubMed computer search was performed to identify relevant articles. Setting: Research institution. Patient(s): Not applicable. Intervention(s): None. Main Outcome Measure(s): Not applicable. Result(s): Studies in animals indicate that in vitro culture may be associated with widespread alterations in imprinted genes compared with in vivo-conceived offspring. Recently, studies in humans have likewise demonstrated widespread changes in DNA methylation, including genes linked to adipocyte development, insulin signaling, and obesity in offspring conceived by ART compared with in vivo-conceived children. Changes in multiple imprinted genes after ART also were noted in additional studies, which suggested that the diagnosis of infertility may explain the differences between in vivo-conceived and ART offspring. Conclusion(s): These data suggest that ART is associated with widespread epigenetic modifications in phenotypically normal children, and that these modifications may increase the risk of adverse cardiometabolic outcomes. Further research is needed to elucidate the possible relationship between ART, genome-wide alterations in imprinted genes, and their potential relevance to subtle cardiometabolic consequences reported in ART offspring.
AB - Objective: To review recent data regarding subtle, but widespread, epigenetic alterations in phenotypically normal offspring conceived by assisted reproductive technologies (ART) compared with offspring conceived in vivo. Design: A PubMed computer search was performed to identify relevant articles. Setting: Research institution. Patient(s): Not applicable. Intervention(s): None. Main Outcome Measure(s): Not applicable. Result(s): Studies in animals indicate that in vitro culture may be associated with widespread alterations in imprinted genes compared with in vivo-conceived offspring. Recently, studies in humans have likewise demonstrated widespread changes in DNA methylation, including genes linked to adipocyte development, insulin signaling, and obesity in offspring conceived by ART compared with in vivo-conceived children. Changes in multiple imprinted genes after ART also were noted in additional studies, which suggested that the diagnosis of infertility may explain the differences between in vivo-conceived and ART offspring. Conclusion(s): These data suggest that ART is associated with widespread epigenetic modifications in phenotypically normal children, and that these modifications may increase the risk of adverse cardiometabolic outcomes. Further research is needed to elucidate the possible relationship between ART, genome-wide alterations in imprinted genes, and their potential relevance to subtle cardiometabolic consequences reported in ART offspring.
KW - Genome-wide epigenetics
KW - assisted reproductive technology
KW - cardiometabolic
KW - epigenetics
KW - imprinting
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U2 - 10.1016/j.fertnstert.2011.09.037
DO - 10.1016/j.fertnstert.2011.09.037
M3 - Review article
C2 - 22035969
AN - SCOPUS:82455187928
SN - 0015-0282
VL - 96
SP - 1306
EP - 1311
JO - Fertility and sterility
JF - Fertility and sterility
IS - 6
ER -