TY - JOUR
T1 - Are there specific components of the insulin resistance syndrome that predict the increased atherosclerosis seen in type 2 diabetes mellitus?
AU - Golden, Sherita Hill
AU - Chong, Rachel
N1 - Funding Information:
Dr. Golden is supported by a grant through the Robert Wood Johnson Foundation Minority Medical Faculty Development Program, Princeton, NJ, and a minority supplement from a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (3 UO1 DK 48485-10S1).
PY - 2004/2
Y1 - 2004/2
N2 - Cardiovascular disease is often present in patients with newly diagnosed type 2 diabetes. It is hypothesized that both type 2 diabetes and cardiovascular disease arise from an underlying insulin resistance syndrome, including impaired glucose tolerance, hypertension, dyslipidemia, and abdominal obesity. We reviewed the literature using various epidemiologic techniques to evaluate the relation between the insulin resistance syndrome components and incident cardiovascular disease. We found that although insulin resistance is likely important in the development of cardiovascular disease seen in diabetes, lipid and blood pressure abnormalities associated with the syndrome appear to be equally important. Future studies are needed to determine the most effective treatment strategies for preventing cardiovascular disease associated with the insulin resistance syndrome and type 2 diabetes.
AB - Cardiovascular disease is often present in patients with newly diagnosed type 2 diabetes. It is hypothesized that both type 2 diabetes and cardiovascular disease arise from an underlying insulin resistance syndrome, including impaired glucose tolerance, hypertension, dyslipidemia, and abdominal obesity. We reviewed the literature using various epidemiologic techniques to evaluate the relation between the insulin resistance syndrome components and incident cardiovascular disease. We found that although insulin resistance is likely important in the development of cardiovascular disease seen in diabetes, lipid and blood pressure abnormalities associated with the syndrome appear to be equally important. Future studies are needed to determine the most effective treatment strategies for preventing cardiovascular disease associated with the insulin resistance syndrome and type 2 diabetes.
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U2 - 10.1007/s11892-004-0007-7
DO - 10.1007/s11892-004-0007-7
M3 - Review article
C2 - 14764276
AN - SCOPUS:1642297251
SN - 1534-4827
VL - 4
SP - 26
EP - 30
JO - Current diabetes reports
JF - Current diabetes reports
IS - 1
ER -