Are synaptic MAGUK proteins involved in chronic pain?

Yuan Xiang Tao, Srinivasa N. Raja

Research output: Contribution to journalShort surveypeer-review

Abstract

Chronic pain, particularly neuropathic pain, is notoriously difficult to treat. NMDA receptor antagonists are effective in reducing pain hypersensitivity in animal models and clinical settings but are associated with an unacceptable level of side-effects. Recent studies of the role of a family of synaptic membrane-associated guanylate kinase proteins in chronic pain provide new insights into central mechanisms of chronic pain that could result in new biochemical targets for its treatment.

Original languageEnglish (US)
Pages (from-to)397-400
Number of pages4
JournalTrends in Pharmacological Sciences
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2004

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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