Are mental diseases brain diseases? The contribution of neuropathology to understanding of schizophrenic psychoses

Michael B. Knable, Daniel Weinberger

Research output: Contribution to journalArticle

Abstract

Nearly a century after the seminal contributions of Emil Kraepelin, the search for neuropathologic correlates of schizophrenic psychoses continues. A multitude of neuroanatomic and neurochemical findings has emerged in recent years, but many of these findings are not replicated or are difficult to interpret in light of methodologic problems. In this review replicated neuropathologic and neuroimaging studies are discussed. The hypothesis that emerges from these studies is that schizophrenia is a developmental abnormality affecting the connectivity of the prefrontal and medial temporal cortices.

Original languageEnglish (US)
Pages (from-to)224-230
Number of pages7
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume245
Issue number4-5
DOIs
StatePublished - Jul 1995
Externally publishedYes

Fingerprint

Brain Diseases
Temporal Lobe
Neuroimaging
Psychotic Disorders
Schizophrenia
Neuropathology

Keywords

  • Neuroimaging
  • Neuropathology
  • Psychosis
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

Cite this

@article{e4039508debe43e799735ca1fa36406f,
title = "Are mental diseases brain diseases? The contribution of neuropathology to understanding of schizophrenic psychoses",
abstract = "Nearly a century after the seminal contributions of Emil Kraepelin, the search for neuropathologic correlates of schizophrenic psychoses continues. A multitude of neuroanatomic and neurochemical findings has emerged in recent years, but many of these findings are not replicated or are difficult to interpret in light of methodologic problems. In this review replicated neuropathologic and neuroimaging studies are discussed. The hypothesis that emerges from these studies is that schizophrenia is a developmental abnormality affecting the connectivity of the prefrontal and medial temporal cortices.",
keywords = "Neuroimaging, Neuropathology, Psychosis, Schizophrenia",
author = "Knable, {Michael B.} and Daniel Weinberger",
year = "1995",
month = "7",
doi = "10.1007/BF02191801",
language = "English (US)",
volume = "245",
pages = "224--230",
journal = "European Archives of Psychiatry and Clinical Neuroscience",
issn = "0940-1334",
publisher = "D. Steinkopff-Verlag",
number = "4-5",

}

TY - JOUR

T1 - Are mental diseases brain diseases? The contribution of neuropathology to understanding of schizophrenic psychoses

AU - Knable, Michael B.

AU - Weinberger, Daniel

PY - 1995/7

Y1 - 1995/7

N2 - Nearly a century after the seminal contributions of Emil Kraepelin, the search for neuropathologic correlates of schizophrenic psychoses continues. A multitude of neuroanatomic and neurochemical findings has emerged in recent years, but many of these findings are not replicated or are difficult to interpret in light of methodologic problems. In this review replicated neuropathologic and neuroimaging studies are discussed. The hypothesis that emerges from these studies is that schizophrenia is a developmental abnormality affecting the connectivity of the prefrontal and medial temporal cortices.

AB - Nearly a century after the seminal contributions of Emil Kraepelin, the search for neuropathologic correlates of schizophrenic psychoses continues. A multitude of neuroanatomic and neurochemical findings has emerged in recent years, but many of these findings are not replicated or are difficult to interpret in light of methodologic problems. In this review replicated neuropathologic and neuroimaging studies are discussed. The hypothesis that emerges from these studies is that schizophrenia is a developmental abnormality affecting the connectivity of the prefrontal and medial temporal cortices.

KW - Neuroimaging

KW - Neuropathology

KW - Psychosis

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0029003467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029003467&partnerID=8YFLogxK

U2 - 10.1007/BF02191801

DO - 10.1007/BF02191801

M3 - Article

VL - 245

SP - 224

EP - 230

JO - European Archives of Psychiatry and Clinical Neuroscience

JF - European Archives of Psychiatry and Clinical Neuroscience

SN - 0940-1334

IS - 4-5

ER -