Are mental diseases brain diseases? The contribution of neuropathology to understanding of schizophrenic psychoses

Michael B. Knable, Daniel R. Weinberger

Research output: Contribution to journalArticlepeer-review

Abstract

Nearly a century after the seminal contributions of Emil Kraepelin, the search for neuropathologic correlates of schizophrenic psychoses continues. A multitude of neuroanatomic and neurochemical findings has emerged in recent years, but many of these findings are not replicated or are difficult to interpret in light of methodologic problems. In this review replicated neuropathologic and neuroimaging studies are discussed. The hypothesis that emerges from these studies is that schizophrenia is a developmental abnormality affecting the connectivity of the prefrontal and medial temporal cortices.

Original languageEnglish (US)
Pages (from-to)224-230
Number of pages7
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume245
Issue number4-5
DOIs
StatePublished - Jul 1 1995
Externally publishedYes

Keywords

  • Neuroimaging
  • Neuropathology
  • Psychosis
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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