Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer?

V. C. Karande, R. G. Lester, S. J. Muasher, D. L. Jones, A. A. Acosta, H. W. Jones

Research output: Contribution to journalArticlepeer-review

Abstract

Forty-six infertile women with a history of diethylstilbestrol (DES) exposure in utero underwent 149 stimulation attempts for in vitro fertilization (IVF). The mean (± SE) number of preovulatory oocytes harvested at retrieval and transferred was 3.9 ± 3.3 (536/138) and 2.6 ± 1.4 (328/124). When compared with patients with tubal factor infertility and ≤ 4 pre-embryos transferred, the clinical pregnancy rate (15.3% versus 22%) was not statistically different. However, the term/ongoing pregnancy rate was significantly lower in the study group (8% versus 16%). Comparison of the IVF outcome with different uterone anomalies as detected by hysterosalpingogram (n = 29) showed a trend for a worse prognosis in women with constrictions and a combination of T-shape and constrictions. It is concluded that implantation and pregnancy outcome are impaired in DES-exposed women after IVF.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalFertility and sterility
Volume54
Issue number2
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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