ArcA regulator of gamma-proteobacteria: Identification of the binding signal and description of the regulon

A. V. Gerasimova, M. S. Gelfand, V. Yu Makeev, A. A. Mironov, A. V. Favorov

Research output: Contribution to journalArticle

Abstract

Basing on a common signal previously identified in nine regions upstream of Escherichia coli genes regulated by ArcA, orthologous ArcA-regulated genes were identified in genomes of gamma-proteobacteria: Escherichia coli, Yersinia pestis, Pasteurella multocida, and Vibrio vulnificus. In addition to 10 genes in the training set, 23 new genes with conserved candidate ArcA-binding sites were identified. Fourteen of them have been described in the literature as transcriptionally regulated depending on the oxygen level. A candidate site upstream of arcA makes it plausible that this gene is autoregulated by the negative feedback loop mechanism.

Original languageEnglish (US)
Pages (from-to)S21-S25
JournalBiophysics
Volume48
Issue numberSUPPL1
StatePublished - Dec 1 2003
Externally publishedYes

Keywords

  • Aerobic-anaerobic switch
  • ArcA
  • Gamma-proteobacteria
  • Gibbs sampler
  • Protein binding site
  • Protein-DNA binding
  • Regulation of transcription
  • SeSiMCMC

ASJC Scopus subject areas

  • Biophysics

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    Gerasimova, A. V., Gelfand, M. S., Makeev, V. Y., Mironov, A. A., & Favorov, A. V. (2003). ArcA regulator of gamma-proteobacteria: Identification of the binding signal and description of the regulon. Biophysics, 48(SUPPL1), S21-S25.