Aragon workers' health study - design and cohort description

José A. Casasnovas, Victor Alcaide, Fernando Civeira, Eliseo Guallar, Borja Ibañez, Jesús J. Borreguero, Martin Laclaustra, Montserrat León, José L. Peñalvo, José M. Ordovás, Miguel Pocovi, Ginés Sanz, Valentín Fuster

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Abstract

Background: Spain, a Mediterranean country with relatively low rates of coronary heart disease, has a high prevalence of traditional cardiovascular risk factors and is experiencing a severe epidemic of overweight/obesity. We designed the Aragon Workers' Health Study (AWHS) to characterize the factors associated with metabolic abnormalities and subclinical atherosclerosis in a middle aged population in Spain free of clinical cardiovascular disease. The objective of this paper is to describe the study design, aims and baseline characteristics of participants in the AWHS.Methods/Design: Longitudinal cohort study based on the annual health exams of 5,400 workers of a car assembly plant in Figueruelas (Zaragoza, Spain). Study participants were recruited during a standardized clinical exam in 2009-2010 (participation rate 95.6%). Study participants will undergo annual clinical exams and laboratory assays, and baseline and triennial collection of biological materials for biobanking and cardiovascular imaging exams (carotid, femoral and abdominal ultrasonography, coronary calcium score, and ankle-arm blood pressure index). Participants will be followed-up for 10 years.Results: The average (SD) age, body mass index, and waist circumference were 49.3 (8.7) years, 27.7 (3.6) kg/m2 and 97.2 (9.9) cm, respectively, among males (N = 5,048), and 40.8 (11.6) years, 24.4 (3.8) kg/m2, and 81.9 (9.9) cm, among females (N = 351). The prevalence of overweight, obesity, current smoking, hypertension, hypercholesterolemia, and diabetes were 55.0, 23.1, 37.1, 40.3, 75.0, and 7.4%, respectively, among males, and 23.7, 8.3, 45.0, 12.1, 59.5, and 0.6%, respectively, among females. In the initial 587 study participants who completed all imaging exams (94.5% male), the prevalence of carotid plaque, femoral plaque, coronary calcium score >1 to 100, and coronary calcium score >100 was 30.3, 56.9, 27.0, and 8.8%, respectively. 67.7% of study participants had at least one plaque in the carotid or femoral arteries.Discussion: Baseline data from the AWHS show a high prevalence of cardiovascular risk factors and of sublinical atherosclerosis. Follow-up of this cohort will allow the assessment of subclinical atherosclerosis progression and the link of disease progression to traditional and emergent risk factors.

Original languageEnglish (US)
Article number45
JournalBMC Cardiovascular Disorders
Volume12
DOIs
StatePublished - Jun 19 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Casasnovas, J. A., Alcaide, V., Civeira, F., Guallar, E., Ibañez, B., Borreguero, J. J., Laclaustra, M., León, M., Peñalvo, J. L., Ordovás, J. M., Pocovi, M., Sanz, G., & Fuster, V. (2012). Aragon workers' health study - design and cohort description. BMC Cardiovascular Disorders, 12, [45]. https://doi.org/10.1186/1471-2261-12-45