Arachidonic Acid Metabolites During Nasal Challenge

Mark S. Brown, Stephen P. Peters, N. Franklin Adkinson, David Proud, Anne Kagey-Sobotka, Philip S. Norman, Lawrence M. Lichtenstein, Robert M. Naclerio

Research output: Contribution to journalArticlepeer-review

Abstract

In order to assess the role of arachidonic acid metabolites in the early reaction to antigen, we challenged six allergic individuals with and without premedication with aspirin and recorded their clinical response, as indicated by number of sneezes, and measured the levels of inflammatory mediators. The early reaction to antigen was associated with increases in the levels of histamine, Na-tosyl-l-arginine methyl esterase (TAME-esterase) activity, prostaglandin (PG) D2, leukotriene C4, PGE, and thromboxane. Aspirin significantly inhibited the increases in the cyclooxygenase metabolites PGE, PGD2, PGF, 6-keto-PGF, and thromboxane but did not affect the amount of sneezing or the levels of histamine, TAME-esterase activity, or leukotrienes. The pattern of the metabolites and their response to pretreatment with aspirin parallel the response of purified human lung mast cells, supporting the notion that the early phase of allergic rhinitis is a mast cell—dominated event. (Arch Otolaryngol Head Neck Surg 1987;113:179-183)

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalArchives of Otolaryngology--Head and Neck Surgery
Volume113
Issue number2
DOIs
StatePublished - Feb 1987

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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