Aqueous penetration of moxifloxacin 0.5% ophthalmic solution and besifloxacin 0.6% ophthalmic suspension in cataract surgery patients

Junko Yoshida, Alisa Kim, Kimberly A. Pratzer, Walter J. Stark

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the aqueous humor concentrations of moxifloxacin and besifloxacin after routine preoperative topical dosing in patients having cataract surgery. Setting: Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA. Methods: In this prospective randomized parallel double-masked clinical trial, 1 drop of commercially available moxifloxacin 0.5% ophthalmic solution or besifloxacin 0.6% ophthalmic suspension was administered every 10 minutes for a total of 4 doses beginning 1 hour before routine cataract surgery. Aqueous humor was sampled via the paracentesis, and antibiotic concentrations were determined using validated high-performance liquid chromatography procedures. Results: The study enrolled 50 patients. The aqueous concentration of the antibiotic agent was detectable in all 23 moxifloxacin samples and in 10 (40%) of the 25 besifloxacin samples (P

Original languageEnglish (US)
Pages (from-to)1499-1502
Number of pages4
JournalJournal of Cataract and Refractive Surgery
Volume36
Issue number9
DOIs
StatePublished - Sep 2010

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Ophthalmic Solutions
Cataract
Suspensions
Aqueous Humor
Anti-Bacterial Agents
Paracentesis
Baltimore
High Pressure Liquid Chromatography
Clinical Trials
moxifloxacin
7-(3-aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Surgery
  • Medicine(all)

Cite this

Aqueous penetration of moxifloxacin 0.5% ophthalmic solution and besifloxacin 0.6% ophthalmic suspension in cataract surgery patients. / Yoshida, Junko; Kim, Alisa; Pratzer, Kimberly A.; Stark, Walter J.

In: Journal of Cataract and Refractive Surgery, Vol. 36, No. 9, 09.2010, p. 1499-1502.

Research output: Contribution to journalArticle

Yoshida, Junko ; Kim, Alisa ; Pratzer, Kimberly A. ; Stark, Walter J. / Aqueous penetration of moxifloxacin 0.5% ophthalmic solution and besifloxacin 0.6% ophthalmic suspension in cataract surgery patients. In: Journal of Cataract and Refractive Surgery. 2010 ; Vol. 36, No. 9. pp. 1499-1502.
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