Aquaporins in health and disease

Research output: Contribution to journalArticle

Abstract

The molecular basis of membrane water-permeability remained elusive until the recent discovery of the aquaporin water-channel proteins. The fundamental importance of these proteins is suggested by their conservation from bacteria through plants to mammals. Ten mammalian aquaporins have thus far been identified, each with a distinct distribution. In the kidney, lung, eye and brain, multiple water-channel homologs are expressed, providing a network for water transport in those locations. It is increasingly clear that alterations in aquaporin expression or function can be rate-limiting for water transport across certain membranes. Aquaporins are likely to prove central to the pathophysiology of a variety of clinical conditions from diabetes insipidus to various forms of edema and, ultimately, they could be a target for therapy in diseases of altered water homeostasis.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalMolecular Medicine Today
Volume6
Issue number2
DOIs
StatePublished - 2000

Fingerprint

Aquaporins
Health
Water
Diabetes Insipidus
Membranes
Mammals
Permeability
Edema
Homeostasis
Bacteria
Kidney
Lung
Brain
Proteins

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine

Cite this

Aquaporins in health and disease. / King, Landon Stuart; Yasui, Masato; Agre, Peter C.

In: Molecular Medicine Today, Vol. 6, No. 2, 2000, p. 60-65.

Research output: Contribution to journalArticle

@article{fdfbde74dbdc45599eb5c08576e14062,
title = "Aquaporins in health and disease",
abstract = "The molecular basis of membrane water-permeability remained elusive until the recent discovery of the aquaporin water-channel proteins. The fundamental importance of these proteins is suggested by their conservation from bacteria through plants to mammals. Ten mammalian aquaporins have thus far been identified, each with a distinct distribution. In the kidney, lung, eye and brain, multiple water-channel homologs are expressed, providing a network for water transport in those locations. It is increasingly clear that alterations in aquaporin expression or function can be rate-limiting for water transport across certain membranes. Aquaporins are likely to prove central to the pathophysiology of a variety of clinical conditions from diabetes insipidus to various forms of edema and, ultimately, they could be a target for therapy in diseases of altered water homeostasis.",
author = "King, {Landon Stuart} and Masato Yasui and Agre, {Peter C}",
year = "2000",
doi = "10.1016/S1357-4310(99)01636-6",
language = "English (US)",
volume = "6",
pages = "60--65",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Aquaporins in health and disease

AU - King, Landon Stuart

AU - Yasui, Masato

AU - Agre, Peter C

PY - 2000

Y1 - 2000

N2 - The molecular basis of membrane water-permeability remained elusive until the recent discovery of the aquaporin water-channel proteins. The fundamental importance of these proteins is suggested by their conservation from bacteria through plants to mammals. Ten mammalian aquaporins have thus far been identified, each with a distinct distribution. In the kidney, lung, eye and brain, multiple water-channel homologs are expressed, providing a network for water transport in those locations. It is increasingly clear that alterations in aquaporin expression or function can be rate-limiting for water transport across certain membranes. Aquaporins are likely to prove central to the pathophysiology of a variety of clinical conditions from diabetes insipidus to various forms of edema and, ultimately, they could be a target for therapy in diseases of altered water homeostasis.

AB - The molecular basis of membrane water-permeability remained elusive until the recent discovery of the aquaporin water-channel proteins. The fundamental importance of these proteins is suggested by their conservation from bacteria through plants to mammals. Ten mammalian aquaporins have thus far been identified, each with a distinct distribution. In the kidney, lung, eye and brain, multiple water-channel homologs are expressed, providing a network for water transport in those locations. It is increasingly clear that alterations in aquaporin expression or function can be rate-limiting for water transport across certain membranes. Aquaporins are likely to prove central to the pathophysiology of a variety of clinical conditions from diabetes insipidus to various forms of edema and, ultimately, they could be a target for therapy in diseases of altered water homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=0033969517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033969517&partnerID=8YFLogxK

U2 - 10.1016/S1357-4310(99)01636-6

DO - 10.1016/S1357-4310(99)01636-6

M3 - Article

C2 - 10652478

AN - SCOPUS:0033969517

VL - 6

SP - 60

EP - 65

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 2

ER -