TY - JOUR
T1 - Aquaporin water channels
T2 - unanswered questions and unresolved controversies
AU - Agre, Peter
AU - Brown, Dennis
AU - Nielsen, Søren
N1 - Funding Information:
The authors thank the members of their own laboratories, Gregory M Preston, Landon King, Mary Macgill, Care1 van OS, Mark L Zeidel, Jin Sup Jung, Maarten Chrispeels, and Mark A Knepper for suggestionsT. his work was supportedb y NIH grants HL33991, HL48268, DK38452, the Danish Medical Research Council, the BiomembraneR esearch Center and Foundation of the University of Aarhus, and the Novo Foundation.
PY - 1995
Y1 - 1995
N2 - The long-standing biophysical question of how water crosses plasma membranes has been answered by the recent discovery of the aquaporins. Identification of this large family of membrane water-transport proteins has generated new questions about the physiological functions, tissue distributions, and regulatory mechanisms of individual aquaporins. The fast pace of developments in this field has also resulted in major discrepancies in published reports which warrant resolution.
AB - The long-standing biophysical question of how water crosses plasma membranes has been answered by the recent discovery of the aquaporins. Identification of this large family of membrane water-transport proteins has generated new questions about the physiological functions, tissue distributions, and regulatory mechanisms of individual aquaporins. The fast pace of developments in this field has also resulted in major discrepancies in published reports which warrant resolution.
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U2 - 10.1016/0955-0674(95)80003-4
DO - 10.1016/0955-0674(95)80003-4
M3 - Article
C2 - 7495566
AN - SCOPUS:0029151790
SN - 0955-0674
VL - 7
SP - 472
EP - 483
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 4
ER -