Aquaporin water channels: Molecular mechanisms for human diseases

Peter Agre, David Kozono

Research output: Contribution to journalArticle

Abstract

Although water is the major component of all biological fluids, the molecular pathways for water transport across cell membranes eluded identification until the discovery of the aquaporin family of water channels. The atomic structure of mammalian AQP1 illustrates how this family of proteins is freely permeated by water but not protons (hydronium ions, H 3O+). Definition of the subcellular sites of expression predicted their physiological functions and potential clinical disorders. Analysis of several human disease states has confirmed that aquaporins are involved in multiple different illnesses including abnormalities of kidney function, loss of vision, onset of brain edema, starvation, and arsenic toxicity.

Original languageEnglish (US)
Pages (from-to)72-78
Number of pages7
JournalFEBS Letters
Volume555
Issue number1
DOIs
StatePublished - Nov 27 2003

Keywords

  • Aquaporin
  • Human disease
  • Membrane water channel
  • Structure and function

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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