Aquaporin Water Channels

Kun Liu, P. Agre

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Aquaporins (AQPs) are a family of integral membrane proteins, through which water and other small molecules pass across the lipid bilayer at high capacity. They are ubiquitously present in all five kingdoms of living organisms, consistent with the fundamental significance of water homeostasis for life. Since the discovery of the first aquaporin, AQP-1, various aquaporins have been found to play important roles in many physiological processes. The determination of AQP structures at atomic resolution and biochemical studies implicate the potential as drug targets for genetic or infectious diseases.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages120-126
Number of pages7
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Keywords

  • Aquaglyceroporin
  • Aquaporin
  • Pathophysiology
  • Water homeostasis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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