Aquaporin-4 IgG seropositivity is associated with worse visual outcomes after optic neuritis than MOG-IgG seropositivity and multiple sclerosis, independent of macular ganglion cell layer thinning

Elias S. Sotirchos, Angeliki Filippatou, Kathryn Fitzgerald, Sara Salama, Santiago Pardo, Jiangxia Wang, Esther Ogbuokiri, Norah J. Cowley, Nicole Pellegrini, Olwen C. Murphy, Maureen A. Mealy, Jerry L. Prince, Michael Levy, Peter Calabresi, Shiv Saidha

Research output: Contribution to journalArticle

Abstract

Background: Comparative studies of characteristics of optic neuritis (ON) associated with myelin oligodendrocyte glycoprotein-IgG (MOG-ON) and aquaporin-4-IgG (AQP4-ON) seropositivity are limited. Objective: To compare visual and optical coherence tomography (OCT) measures following AQP4-ON, MOG-ON, and multiple sclerosis associated ON (MS-ON). Methods: In this cross-sectional study, 48 AQP4-ON, 16 MOG-ON, 40 MS-ON, and 31 healthy control participants underwent monocular letter-acuity assessment and spectral-domain OCT. Eyes with a history of ON >3 months prior to evaluation were analyzed. Results: AQP4-ON eyes exhibited worse high-contrast letter acuity (HCLA) compared to MOG-ON (−22.3 ± 3.9 letters; p < 0.001) and MS-ON eyes (−21.7 ± 4.0 letters; p < 0.001). Macular ganglion cell + inner plexiform layer (GCIPL) thickness was lower, as compared to MS-ON, in AQP4-ON (−9.1 ± 2.0 µm; p < 0.001) and MOG-ON (−7.6 ± 2.2 µm; p = 0.001) eyes. Lower GCIPL thickness was associated with worse HCLA in AQP4-ON (−16.5 ± 1.5 letters per 10 µm decrease; p < 0.001) and MS-ON eyes (−8.5 ± 2.3 letters per 10 µm decrease; p < 0.001), but not in MOG-ON eyes (−5.2 ± 3.8 letters per 10 µm decrease; p = 0.17), and these relationships differed between the AQP4-ON and other ON groups (p < 0.01 for interaction). Conclusion: AQP4-IgG seropositivity is associated with worse visual outcomes after ON compared with MOG-ON and MS-ON, even with similar severity of macular GCIPL thinning.

Original languageEnglish (US)
JournalMultiple Sclerosis Journal
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Aquaporin 4
Optic Neuritis
Ganglia
Multiple Sclerosis
Myelin-Oligodendrocyte Glycoprotein
Immunoglobulin G
Optical Coherence Tomography

Keywords

  • multiple sclerosis
  • myelin oligodendrocyte glycoprotein
  • neuromyelitis optica
  • Optic neuritis
  • optical coherence tomography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Aquaporin-4 IgG seropositivity is associated with worse visual outcomes after optic neuritis than MOG-IgG seropositivity and multiple sclerosis, independent of macular ganglion cell layer thinning. / Sotirchos, Elias S.; Filippatou, Angeliki; Fitzgerald, Kathryn; Salama, Sara; Pardo, Santiago; Wang, Jiangxia; Ogbuokiri, Esther; Cowley, Norah J.; Pellegrini, Nicole; Murphy, Olwen C.; Mealy, Maureen A.; Prince, Jerry L.; Levy, Michael; Calabresi, Peter; Saidha, Shiv.

In: Multiple Sclerosis Journal, 01.01.2019.

Research output: Contribution to journalArticle

Sotirchos, Elias S. ; Filippatou, Angeliki ; Fitzgerald, Kathryn ; Salama, Sara ; Pardo, Santiago ; Wang, Jiangxia ; Ogbuokiri, Esther ; Cowley, Norah J. ; Pellegrini, Nicole ; Murphy, Olwen C. ; Mealy, Maureen A. ; Prince, Jerry L. ; Levy, Michael ; Calabresi, Peter ; Saidha, Shiv. / Aquaporin-4 IgG seropositivity is associated with worse visual outcomes after optic neuritis than MOG-IgG seropositivity and multiple sclerosis, independent of macular ganglion cell layer thinning. In: Multiple Sclerosis Journal. 2019.
@article{96313cc905244515973212d42dfda10e,
title = "Aquaporin-4 IgG seropositivity is associated with worse visual outcomes after optic neuritis than MOG-IgG seropositivity and multiple sclerosis, independent of macular ganglion cell layer thinning",
abstract = "Background: Comparative studies of characteristics of optic neuritis (ON) associated with myelin oligodendrocyte glycoprotein-IgG (MOG-ON) and aquaporin-4-IgG (AQP4-ON) seropositivity are limited. Objective: To compare visual and optical coherence tomography (OCT) measures following AQP4-ON, MOG-ON, and multiple sclerosis associated ON (MS-ON). Methods: In this cross-sectional study, 48 AQP4-ON, 16 MOG-ON, 40 MS-ON, and 31 healthy control participants underwent monocular letter-acuity assessment and spectral-domain OCT. Eyes with a history of ON >3 months prior to evaluation were analyzed. Results: AQP4-ON eyes exhibited worse high-contrast letter acuity (HCLA) compared to MOG-ON (−22.3 ± 3.9 letters; p < 0.001) and MS-ON eyes (−21.7 ± 4.0 letters; p < 0.001). Macular ganglion cell + inner plexiform layer (GCIPL) thickness was lower, as compared to MS-ON, in AQP4-ON (−9.1 ± 2.0 µm; p < 0.001) and MOG-ON (−7.6 ± 2.2 µm; p = 0.001) eyes. Lower GCIPL thickness was associated with worse HCLA in AQP4-ON (−16.5 ± 1.5 letters per 10 µm decrease; p < 0.001) and MS-ON eyes (−8.5 ± 2.3 letters per 10 µm decrease; p < 0.001), but not in MOG-ON eyes (−5.2 ± 3.8 letters per 10 µm decrease; p = 0.17), and these relationships differed between the AQP4-ON and other ON groups (p < 0.01 for interaction). Conclusion: AQP4-IgG seropositivity is associated with worse visual outcomes after ON compared with MOG-ON and MS-ON, even with similar severity of macular GCIPL thinning.",
keywords = "multiple sclerosis, myelin oligodendrocyte glycoprotein, neuromyelitis optica, Optic neuritis, optical coherence tomography",
author = "Sotirchos, {Elias S.} and Angeliki Filippatou and Kathryn Fitzgerald and Sara Salama and Santiago Pardo and Jiangxia Wang and Esther Ogbuokiri and Cowley, {Norah J.} and Nicole Pellegrini and Murphy, {Olwen C.} and Mealy, {Maureen A.} and Prince, {Jerry L.} and Michael Levy and Peter Calabresi and Shiv Saidha",
year = "2019",
month = "1",
day = "1",
doi = "10.1177/1352458519864928",
language = "English (US)",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",

}

TY - JOUR

T1 - Aquaporin-4 IgG seropositivity is associated with worse visual outcomes after optic neuritis than MOG-IgG seropositivity and multiple sclerosis, independent of macular ganglion cell layer thinning

AU - Sotirchos, Elias S.

AU - Filippatou, Angeliki

AU - Fitzgerald, Kathryn

AU - Salama, Sara

AU - Pardo, Santiago

AU - Wang, Jiangxia

AU - Ogbuokiri, Esther

AU - Cowley, Norah J.

AU - Pellegrini, Nicole

AU - Murphy, Olwen C.

AU - Mealy, Maureen A.

AU - Prince, Jerry L.

AU - Levy, Michael

AU - Calabresi, Peter

AU - Saidha, Shiv

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Comparative studies of characteristics of optic neuritis (ON) associated with myelin oligodendrocyte glycoprotein-IgG (MOG-ON) and aquaporin-4-IgG (AQP4-ON) seropositivity are limited. Objective: To compare visual and optical coherence tomography (OCT) measures following AQP4-ON, MOG-ON, and multiple sclerosis associated ON (MS-ON). Methods: In this cross-sectional study, 48 AQP4-ON, 16 MOG-ON, 40 MS-ON, and 31 healthy control participants underwent monocular letter-acuity assessment and spectral-domain OCT. Eyes with a history of ON >3 months prior to evaluation were analyzed. Results: AQP4-ON eyes exhibited worse high-contrast letter acuity (HCLA) compared to MOG-ON (−22.3 ± 3.9 letters; p < 0.001) and MS-ON eyes (−21.7 ± 4.0 letters; p < 0.001). Macular ganglion cell + inner plexiform layer (GCIPL) thickness was lower, as compared to MS-ON, in AQP4-ON (−9.1 ± 2.0 µm; p < 0.001) and MOG-ON (−7.6 ± 2.2 µm; p = 0.001) eyes. Lower GCIPL thickness was associated with worse HCLA in AQP4-ON (−16.5 ± 1.5 letters per 10 µm decrease; p < 0.001) and MS-ON eyes (−8.5 ± 2.3 letters per 10 µm decrease; p < 0.001), but not in MOG-ON eyes (−5.2 ± 3.8 letters per 10 µm decrease; p = 0.17), and these relationships differed between the AQP4-ON and other ON groups (p < 0.01 for interaction). Conclusion: AQP4-IgG seropositivity is associated with worse visual outcomes after ON compared with MOG-ON and MS-ON, even with similar severity of macular GCIPL thinning.

AB - Background: Comparative studies of characteristics of optic neuritis (ON) associated with myelin oligodendrocyte glycoprotein-IgG (MOG-ON) and aquaporin-4-IgG (AQP4-ON) seropositivity are limited. Objective: To compare visual and optical coherence tomography (OCT) measures following AQP4-ON, MOG-ON, and multiple sclerosis associated ON (MS-ON). Methods: In this cross-sectional study, 48 AQP4-ON, 16 MOG-ON, 40 MS-ON, and 31 healthy control participants underwent monocular letter-acuity assessment and spectral-domain OCT. Eyes with a history of ON >3 months prior to evaluation were analyzed. Results: AQP4-ON eyes exhibited worse high-contrast letter acuity (HCLA) compared to MOG-ON (−22.3 ± 3.9 letters; p < 0.001) and MS-ON eyes (−21.7 ± 4.0 letters; p < 0.001). Macular ganglion cell + inner plexiform layer (GCIPL) thickness was lower, as compared to MS-ON, in AQP4-ON (−9.1 ± 2.0 µm; p < 0.001) and MOG-ON (−7.6 ± 2.2 µm; p = 0.001) eyes. Lower GCIPL thickness was associated with worse HCLA in AQP4-ON (−16.5 ± 1.5 letters per 10 µm decrease; p < 0.001) and MS-ON eyes (−8.5 ± 2.3 letters per 10 µm decrease; p < 0.001), but not in MOG-ON eyes (−5.2 ± 3.8 letters per 10 µm decrease; p = 0.17), and these relationships differed between the AQP4-ON and other ON groups (p < 0.01 for interaction). Conclusion: AQP4-IgG seropositivity is associated with worse visual outcomes after ON compared with MOG-ON and MS-ON, even with similar severity of macular GCIPL thinning.

KW - multiple sclerosis

KW - myelin oligodendrocyte glycoprotein

KW - neuromyelitis optica

KW - Optic neuritis

KW - optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=85070406093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070406093&partnerID=8YFLogxK

U2 - 10.1177/1352458519864928

DO - 10.1177/1352458519864928

M3 - Article

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

ER -