Optimaler akquisitionszeitpunkt für die herz-PET mit 18F-FDG nach oraler glukosebelastung

Translated title of the contribution: Appropriate uptake period for myocardial PET imaging with 18F-FDG after oral glucose loading

I. Brink, E. U. Nitzsche, M. Mix, T. Schindler, M. Hentschel, S. Högerle, E. Moser

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Identification of a rationale for the appropriate uptake period for myocardial 18F-FDG-PET imaging of patients with and without diabetes mellitus. Methods: In a subset of 27 patients, static 2D-PET examination was performed of patients with chronic coronary artery disease and known myocardial infarction. The patients fasted (at least 4 h) before examination. 18F-FDG (330 ± 20 MBq) was injected intravenously. The image quality was semiquantitativly determined by ROI-analysis and the myocardium-to-blood pool activity ratio (M/B) was calculated. I.) Scans 30, 60, and 90 min p. i. of 10 non-diabetic patients (60 g oral glucose loading one hour before FDG-injection, low-dose intravenous insulin bolus if necessary). II.) Scans 30, 60, and 90 min p. i. of 10 patients with known non-insulin dependent diabetes (20 g glucose, insulin bolus). III.) Scans 90 min p. i. of 7 patients with known non-insulin dependent diabetes and elevated fasting serum glucose level (140-200 mg/dl; insulin bolus, no glucose). Results: I.) The M/B ratio significantly increases in non-diabetic patients with the uptake time (30 min 1.95 ± 0.20; 60 min 2.96 ± 0.36; 90 min 3.78 ± 0.43). II.) In patients with non-insulin dependent diabetes the M/B ratio also significantly increases with uptake time. Compared to non-diabetic patients group II reached smaller M/B values (30 min 1.56 ± 0.10; 60 min 2.15 ± 0.14; 90 min 2.71 ± 0.19). III.) In the group of patients with elevated fasting serum glucose level (who only got insulin but no glucose loading) the M/B activity ratio 90 min p. i. was clearly inferior compared with diabetic patients after oral glucose loading and insulin administration (M/B 2.71 ± 0.19 versus 2.16 ± 0.07). Conclusions: In static myocardial viability PET studies with 18F-FDG an uptake time of 90 min yields image quality superior to that obtained after shorter uptake time.

Translated title of the contributionAppropriate uptake period for myocardial PET imaging with 18F-FDG after oral glucose loading
Original languageGerman
Pages (from-to)39-44
Number of pages6
JournalNuklearMedizin
Volume42
Issue number1
DOIs
StatePublished - Feb 2003
Externally publishedYes

Keywords

  • F-FD6 PET
  • Myocardium
  • Uptake
  • Viability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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