Approaching brain injury after cardiac arrest: from bench to bedside

Romergryko G. Geocadin, Shanbao Tong, Anastasios Bezerianos, Seth Smith, Tatsuaki Iwamoto, Nitish V. Thakor, Daniel F. Hanley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The neurological injury after resuscitation from cardiac arrest (CA) is a major cause of morbidity and mortality. The unavailability of primary brain directed measures of injury and effective therapy worsens the problem. We have embarked on better understanding the process of injury and recovery by developing an animal model in our laboratory. Using this model, we have discovered that the use of quantitative EEG (Q-EEG) analysis will allow us to titrate the brain injury, monitor the recovery process, study the electrophysiological and biochemical mechanisms of injury and recovery and detect the neuroprotective effect afforded by a drug that prevents neuronal death after injury. With ideas derived from the laboratory research, we have designed a study to test the applicability of QEEG analysis in human subjects resuscitated from cardiac arrest. Our preliminary analysis shows that our measure is able to track the neurological changes of these patients. With this very promising start of this QEEG based measure, we can utilize this technology to develop more rational and effective therapeutic strategies that will improve the neurological outcome in this patient population.

Original languageEnglish (US)
Title of host publicationConference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering
EditorsLaura J. Wolf, Jodi L. Strock
PublisherIEEE Computer Society
Pages277-280
Number of pages4
ISBN (Electronic)0780375793
DOIs
StatePublished - 2003
Event1st International IEEE EMBS Conference on Neural Engineering - Capri Island, Italy
Duration: Mar 20 2003Mar 22 2003

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
Volume2003-January
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Other

Other1st International IEEE EMBS Conference on Neural Engineering
CountryItaly
CityCapri Island
Period3/20/033/22/03

Keywords

  • Animals
  • Biochemical analysis
  • Brain injuries
  • Brain modeling
  • Cardiac arrest
  • Drugs
  • Electroencephalography
  • Laboratories
  • Medical treatment
  • Monitoring

ASJC Scopus subject areas

  • Artificial Intelligence
  • Mechanical Engineering

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