Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics

Jose Perea, Edurne Alvaro, Yolanda Rodríguez, Cristina Gravalos, Eva Sánchez-Tomé, Barbara Rivera, Francisco Colina, Pablo Carbonell, Rogelio González-Sarmiento, Manuel Hidalgo, Miguel Urioste

Research output: Contribution to journalArticle

Abstract

AIM: To characterize clinicopathological and familial features of early-onset colorectal cancer (CRC) and compare features of tumors with and without microsatellite instability (MSI). METHODS: Forty-five patients with CRC aged 45 or younger were included in the study. Clinical information, a three-generation family history, and tumor samples were obtained. MSI status was analyzed and mismatch repair genes were examined in the MSI families. Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies. RESULTS: Early onset CRC is characterized by advanced stage at diagnosis, right colon location, low-grade of differentiation, mucin production, and presence of polyps. Hereditary forms represent at least 21% of cases. Eighty-one percent of patients who died during followup showed a lack of expression of cyclin E, which could be a marker of poor prognosis. β-catenin expression was normal in a high percentage of tumors. CONCLUSION: Early-onset CRC has an important familial component, with a high proportion of tumors showing microsatellite stable. Cyclin E might be a poor prognosis factor.

Original languageEnglish (US)
Pages (from-to)3697-3703
Number of pages7
JournalWorld Journal of Gastroenterology
Volume16
Issue number29
DOIs
StatePublished - Aug 7 2010

Keywords

  • Early onset colorectal cancer
  • Lynch syndrome
  • Microsatellite instability
  • Microsatellite stable colorectal cancer

ASJC Scopus subject areas

  • Gastroenterology

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    Perea, J., Alvaro, E., Rodríguez, Y., Gravalos, C., Sánchez-Tomé, E., Rivera, B., Colina, F., Carbonell, P., González-Sarmiento, R., Hidalgo, M., & Urioste, M. (2010). Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics. World Journal of Gastroenterology, 16(29), 3697-3703. https://doi.org/10.3748/wjg.v16.i29.3697