Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice

Chad A. Glazer, Steven S. Chang, Patrick K. Ha, Joseph A. Califano

Research output: Contribution to journalReview article

Abstract

During the past decade, there has been a significant increase in knowledge regarding the molecular biology and epigenetics of head and neck squamous cell carcinoma (HNSCC). This has been aided by the steady development of new technology and novel techniques aimed at elucidating additional aberrant molecular alterations characteristic of HNSCC, including the advent of high throughput assays and the development of more sophisticated bioinformatics tools. In addition, advancements in the field of cancer epigenetics and microRNA have increased the complexity of understanding HNSCC tumorigenesis. These advances have lead to an increasing number of translational studies in the diagnosis, prognosis, and treatment of head and neck cancer. The end result is that molecular biomarkers, gene detection panels and targeted therapeutics are becoming a reality for the care of patients with HNSCC. In this article, we will focus on the many implications of this research as it pertains to clinical practice and the treatment of HNSCC patients.

Original languageEnglish (US)
Pages (from-to)440-446
Number of pages7
JournalOral Oncology
Volume45
Issue number4-5
DOIs
StatePublished - Apr 1 2009

Keywords

  • Biomarkers
  • DNA methylation
  • EGFR
  • Epigenetics
  • HPV
  • Head and neck squamous cell carcinoma
  • LOH
  • Molecular biology
  • Oral cancer
  • microRNA

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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