Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice

Chad A. Glazer, Steven S. Chang, Patrick K. Ha, Joseph A. Califano

Research output: Contribution to journalArticle

Abstract

During the past decade, there has been a significant increase in knowledge regarding the molecular biology and epigenetics of head and neck squamous cell carcinoma (HNSCC). This has been aided by the steady development of new technology and novel techniques aimed at elucidating additional aberrant molecular alterations characteristic of HNSCC, including the advent of high throughput assays and the development of more sophisticated bioinformatics tools. In addition, advancements in the field of cancer epigenetics and microRNA have increased the complexity of understanding HNSCC tumorigenesis. These advances have lead to an increasing number of translational studies in the diagnosis, prognosis, and treatment of head and neck cancer. The end result is that molecular biomarkers, gene detection panels and targeted therapeutics are becoming a reality for the care of patients with HNSCC. In this article, we will focus on the many implications of this research as it pertains to clinical practice and the treatment of HNSCC patients.

Original languageEnglish (US)
Pages (from-to)440-446
Number of pages7
JournalOral Oncology
Volume45
Issue number4-5
DOIs
StatePublished - Apr 2009

Fingerprint

Head and Neck Neoplasms
Epigenomics
Molecular Biology
Computational Biology
MicroRNAs
Patient Care
Carcinogenesis
Therapeutics
Biomarkers
Carcinoma, squamous cell of head and neck
Technology
Research
Genes
Neoplasms

Keywords

  • Biomarkers
  • DNA methylation
  • EGFR
  • Epigenetics
  • Head and neck squamous cell carcinoma
  • HPV
  • LOH
  • microRNA
  • Molecular biology
  • Oral cancer

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

Cite this

Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice. / Glazer, Chad A.; Chang, Steven S.; Ha, Patrick K.; Califano, Joseph A.

In: Oral Oncology, Vol. 45, No. 4-5, 04.2009, p. 440-446.

Research output: Contribution to journalArticle

Glazer, Chad A. ; Chang, Steven S. ; Ha, Patrick K. ; Califano, Joseph A. / Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice. In: Oral Oncology. 2009 ; Vol. 45, No. 4-5. pp. 440-446.
@article{8fa5517e14bf44e6b0fef25887cb0e85,
title = "Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice",
abstract = "During the past decade, there has been a significant increase in knowledge regarding the molecular biology and epigenetics of head and neck squamous cell carcinoma (HNSCC). This has been aided by the steady development of new technology and novel techniques aimed at elucidating additional aberrant molecular alterations characteristic of HNSCC, including the advent of high throughput assays and the development of more sophisticated bioinformatics tools. In addition, advancements in the field of cancer epigenetics and microRNA have increased the complexity of understanding HNSCC tumorigenesis. These advances have lead to an increasing number of translational studies in the diagnosis, prognosis, and treatment of head and neck cancer. The end result is that molecular biomarkers, gene detection panels and targeted therapeutics are becoming a reality for the care of patients with HNSCC. In this article, we will focus on the many implications of this research as it pertains to clinical practice and the treatment of HNSCC patients.",
keywords = "Biomarkers, DNA methylation, EGFR, Epigenetics, Head and neck squamous cell carcinoma, HPV, LOH, microRNA, Molecular biology, Oral cancer",
author = "Glazer, {Chad A.} and Chang, {Steven S.} and Ha, {Patrick K.} and Califano, {Joseph A.}",
year = "2009",
month = "4",
doi = "10.1016/j.oraloncology.2008.05.013",
language = "English (US)",
volume = "45",
pages = "440--446",
journal = "Oral Oncology",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "4-5",

}

TY - JOUR

T1 - Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice

AU - Glazer, Chad A.

AU - Chang, Steven S.

AU - Ha, Patrick K.

AU - Califano, Joseph A.

PY - 2009/4

Y1 - 2009/4

N2 - During the past decade, there has been a significant increase in knowledge regarding the molecular biology and epigenetics of head and neck squamous cell carcinoma (HNSCC). This has been aided by the steady development of new technology and novel techniques aimed at elucidating additional aberrant molecular alterations characteristic of HNSCC, including the advent of high throughput assays and the development of more sophisticated bioinformatics tools. In addition, advancements in the field of cancer epigenetics and microRNA have increased the complexity of understanding HNSCC tumorigenesis. These advances have lead to an increasing number of translational studies in the diagnosis, prognosis, and treatment of head and neck cancer. The end result is that molecular biomarkers, gene detection panels and targeted therapeutics are becoming a reality for the care of patients with HNSCC. In this article, we will focus on the many implications of this research as it pertains to clinical practice and the treatment of HNSCC patients.

AB - During the past decade, there has been a significant increase in knowledge regarding the molecular biology and epigenetics of head and neck squamous cell carcinoma (HNSCC). This has been aided by the steady development of new technology and novel techniques aimed at elucidating additional aberrant molecular alterations characteristic of HNSCC, including the advent of high throughput assays and the development of more sophisticated bioinformatics tools. In addition, advancements in the field of cancer epigenetics and microRNA have increased the complexity of understanding HNSCC tumorigenesis. These advances have lead to an increasing number of translational studies in the diagnosis, prognosis, and treatment of head and neck cancer. The end result is that molecular biomarkers, gene detection panels and targeted therapeutics are becoming a reality for the care of patients with HNSCC. In this article, we will focus on the many implications of this research as it pertains to clinical practice and the treatment of HNSCC patients.

KW - Biomarkers

KW - DNA methylation

KW - EGFR

KW - Epigenetics

KW - Head and neck squamous cell carcinoma

KW - HPV

KW - LOH

KW - microRNA

KW - Molecular biology

KW - Oral cancer

UR - http://www.scopus.com/inward/record.url?scp=67349154104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349154104&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2008.05.013

DO - 10.1016/j.oraloncology.2008.05.013

M3 - Article

C2 - 18674958

AN - SCOPUS:67349154104

VL - 45

SP - 440

EP - 446

JO - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

IS - 4-5

ER -