Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma

Hao Yu, Huiling Lou, Tianyu Zou, Xianlong Wang, Shanshan Jiang, Zhongqing Huang, Yongxing Du, Chunxiu Jiang, Ling Ma, Jianbin Zhu, Wen He, Qihong Rui, Jianyuan Zhou, Zhibo Wen

Research output: Contribution to journalArticle

Abstract

Objectives: To determine the utility of amide proton transfer-weighted (APTw) MR imaging in distinguishing solitary brain metastases (SBMs) from glioblastomas (GBMs). Methods: Forty-five patients with SBMs and 43 patients with GBMs underwent conventional and APT-weighted sequences before clinical intervention. The APTw parameters and relative APTw (rAPTw) parameters in the tumour core and the peritumoral brain zone (PBZ) were obtained and compared between SBMs and GBMs. The receiver-operating characteristic (ROC) curve was used to assess the best parameter for distinguishing between the two groups. Results: The APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the tumour core were not significantly different between the SBM and GBM groups (P = 0.141, 0.361, 0.221, 0.305, 0.578 and 0.448, respectively). However, the APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the PBZ were significantly lower in the SBM group than in the GBM group (P < 0.001). The APTwmin values had the highest area under the ROC curve 0.905 and accuracy 85.2% in discriminating between the two neoplasms. Conclusion: As a noninvasive imaging method, APT-weighted MR imaging can be used to distinguish SBMs from GBMs. Key Points: • APTw values in the tumour core were not different between SBMs and GBMs. • APTw values in peritumoral brain zone were lower in SBMs than in GBMs. • The APTwminwas the best parameter to distinguish SBMs from GBMs.

Original languageEnglish (US)
Pages (from-to)4516-4524
Number of pages9
JournalEuropean Radiology
Volume27
Issue number11
DOIs
StatePublished - Nov 1 2017

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Glioblastoma
Amides
Protons
Neoplasm Metastasis
Brain
Proteins
ROC Curve
Neoplasms

Keywords

  • APT imaging
  • Brain
  • Glioblastoma
  • Magnetic resonance imaging
  • Solitary brain metastases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma. / Yu, Hao; Lou, Huiling; Zou, Tianyu; Wang, Xianlong; Jiang, Shanshan; Huang, Zhongqing; Du, Yongxing; Jiang, Chunxiu; Ma, Ling; Zhu, Jianbin; He, Wen; Rui, Qihong; Zhou, Jianyuan; Wen, Zhibo.

In: European Radiology, Vol. 27, No. 11, 01.11.2017, p. 4516-4524.

Research output: Contribution to journalArticle

Yu, H, Lou, H, Zou, T, Wang, X, Jiang, S, Huang, Z, Du, Y, Jiang, C, Ma, L, Zhu, J, He, W, Rui, Q, Zhou, J & Wen, Z 2017, 'Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma', European Radiology, vol. 27, no. 11, pp. 4516-4524. https://doi.org/10.1007/s00330-017-4867-z
Yu, Hao ; Lou, Huiling ; Zou, Tianyu ; Wang, Xianlong ; Jiang, Shanshan ; Huang, Zhongqing ; Du, Yongxing ; Jiang, Chunxiu ; Ma, Ling ; Zhu, Jianbin ; He, Wen ; Rui, Qihong ; Zhou, Jianyuan ; Wen, Zhibo. / Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma. In: European Radiology. 2017 ; Vol. 27, No. 11. pp. 4516-4524.
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abstract = "Objectives: To determine the utility of amide proton transfer-weighted (APTw) MR imaging in distinguishing solitary brain metastases (SBMs) from glioblastomas (GBMs). Methods: Forty-five patients with SBMs and 43 patients with GBMs underwent conventional and APT-weighted sequences before clinical intervention. The APTw parameters and relative APTw (rAPTw) parameters in the tumour core and the peritumoral brain zone (PBZ) were obtained and compared between SBMs and GBMs. The receiver-operating characteristic (ROC) curve was used to assess the best parameter for distinguishing between the two groups. Results: The APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the tumour core were not significantly different between the SBM and GBM groups (P = 0.141, 0.361, 0.221, 0.305, 0.578 and 0.448, respectively). However, the APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the PBZ were significantly lower in the SBM group than in the GBM group (P < 0.001). The APTwmin values had the highest area under the ROC curve 0.905 and accuracy 85.2{\%} in discriminating between the two neoplasms. Conclusion: As a noninvasive imaging method, APT-weighted MR imaging can be used to distinguish SBMs from GBMs. Key Points: • APTw values in the tumour core were not different between SBMs and GBMs. • APTw values in peritumoral brain zone were lower in SBMs than in GBMs. • The APTwminwas the best parameter to distinguish SBMs from GBMs.",
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T1 - Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma

AU - Yu, Hao

AU - Lou, Huiling

AU - Zou, Tianyu

AU - Wang, Xianlong

AU - Jiang, Shanshan

AU - Huang, Zhongqing

AU - Du, Yongxing

AU - Jiang, Chunxiu

AU - Ma, Ling

AU - Zhu, Jianbin

AU - He, Wen

AU - Rui, Qihong

AU - Zhou, Jianyuan

AU - Wen, Zhibo

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Objectives: To determine the utility of amide proton transfer-weighted (APTw) MR imaging in distinguishing solitary brain metastases (SBMs) from glioblastomas (GBMs). Methods: Forty-five patients with SBMs and 43 patients with GBMs underwent conventional and APT-weighted sequences before clinical intervention. The APTw parameters and relative APTw (rAPTw) parameters in the tumour core and the peritumoral brain zone (PBZ) were obtained and compared between SBMs and GBMs. The receiver-operating characteristic (ROC) curve was used to assess the best parameter for distinguishing between the two groups. Results: The APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the tumour core were not significantly different between the SBM and GBM groups (P = 0.141, 0.361, 0.221, 0.305, 0.578 and 0.448, respectively). However, the APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the PBZ were significantly lower in the SBM group than in the GBM group (P < 0.001). The APTwmin values had the highest area under the ROC curve 0.905 and accuracy 85.2% in discriminating between the two neoplasms. Conclusion: As a noninvasive imaging method, APT-weighted MR imaging can be used to distinguish SBMs from GBMs. Key Points: • APTw values in the tumour core were not different between SBMs and GBMs. • APTw values in peritumoral brain zone were lower in SBMs than in GBMs. • The APTwminwas the best parameter to distinguish SBMs from GBMs.

AB - Objectives: To determine the utility of amide proton transfer-weighted (APTw) MR imaging in distinguishing solitary brain metastases (SBMs) from glioblastomas (GBMs). Methods: Forty-five patients with SBMs and 43 patients with GBMs underwent conventional and APT-weighted sequences before clinical intervention. The APTw parameters and relative APTw (rAPTw) parameters in the tumour core and the peritumoral brain zone (PBZ) were obtained and compared between SBMs and GBMs. The receiver-operating characteristic (ROC) curve was used to assess the best parameter for distinguishing between the two groups. Results: The APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the tumour core were not significantly different between the SBM and GBM groups (P = 0.141, 0.361, 0.221, 0.305, 0.578 and 0.448, respectively). However, the APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the PBZ were significantly lower in the SBM group than in the GBM group (P < 0.001). The APTwmin values had the highest area under the ROC curve 0.905 and accuracy 85.2% in discriminating between the two neoplasms. Conclusion: As a noninvasive imaging method, APT-weighted MR imaging can be used to distinguish SBMs from GBMs. Key Points: • APTw values in the tumour core were not different between SBMs and GBMs. • APTw values in peritumoral brain zone were lower in SBMs than in GBMs. • The APTwminwas the best parameter to distinguish SBMs from GBMs.

KW - APT imaging

KW - Brain

KW - Glioblastoma

KW - Magnetic resonance imaging

KW - Solitary brain metastases

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