TY - JOUR
T1 - Applications of telomerase research in the fight against cancer
AU - McKenzie, Katherine E.
AU - Umbricht, Christopher B.
AU - Sukumar, Saraswati
PY - 1999/3/1
Y1 - 1999/3/1
N2 - Telomerase, an enzyme that confers immortality upon cells and that is active in the majority of human tumors, has emerged as a powerful new marker and potential prognostic indicator and therapeutic target for cancer. Furthermore, investigations into the biology of telomerase have revealed important clues into the causes of cell death and have made progress toward answering one of the most important questions of cancer research - what gives a tumor cell an advantage over normal cells? In this article, we present the current state of telomerate research and critically assess both its potential and the pitfalls of its application in cancer diagnosis and treatment.
AB - Telomerase, an enzyme that confers immortality upon cells and that is active in the majority of human tumors, has emerged as a powerful new marker and potential prognostic indicator and therapeutic target for cancer. Furthermore, investigations into the biology of telomerase have revealed important clues into the causes of cell death and have made progress toward answering one of the most important questions of cancer research - what gives a tumor cell an advantage over normal cells? In this article, we present the current state of telomerate research and critically assess both its potential and the pitfalls of its application in cancer diagnosis and treatment.
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U2 - 10.1016/S1357-4310(98)01429-4
DO - 10.1016/S1357-4310(98)01429-4
M3 - Review article
C2 - 10203735
AN - SCOPUS:0033047756
SN - 1357-4310
VL - 5
SP - 114
EP - 122
JO - Molecular Medicine Today
JF - Molecular Medicine Today
IS - 3
ER -