Applications of proteomics to lab diagnosis

Raghothama Chaerkady, Akhilesh Pandey

Research output: Contribution to journalArticle

Abstract

Detailed and comprehensive characterization of proteins is a major goal of proteomics. This goal has become more realistic today with the latest high-resolution mass spectrometers capable of faster sequencing in a high-throughput fashion and with the emergence of new techniques such as protein and peptide microarrays. A promising area for discovery is the application of these advanced mass spectrometric and other quantitative proteomic methodologies to laboratory diagnosis. This review focuses on the role of proteomics in the development of new laboratory diagnostics and the implications for routine diagnosis and monitoring of diseases.

Original languageEnglish (US)
Pages (from-to)485-498
Number of pages14
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume3
DOIs
StatePublished - 2008

Fingerprint

Proteomics
Protein Array Analysis
Clinical Laboratory Techniques
Peptides
Proteins

Keywords

  • Aptamers
  • Isotope labeling
  • Mass spectrometer
  • Peptide arrays
  • Protein arrays
  • Protein profiling

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Applications of proteomics to lab diagnosis. / Chaerkady, Raghothama; Pandey, Akhilesh.

In: Annual Review of Pathology: Mechanisms of Disease, Vol. 3, 2008, p. 485-498.

Research output: Contribution to journalArticle

Chaerkady, Raghothama ; Pandey, Akhilesh. / Applications of proteomics to lab diagnosis. In: Annual Review of Pathology: Mechanisms of Disease. 2008 ; Vol. 3. pp. 485-498.
@article{88a8402c38414b258d239ed66a24059a,
title = "Applications of proteomics to lab diagnosis",
abstract = "Detailed and comprehensive characterization of proteins is a major goal of proteomics. This goal has become more realistic today with the latest high-resolution mass spectrometers capable of faster sequencing in a high-throughput fashion and with the emergence of new techniques such as protein and peptide microarrays. A promising area for discovery is the application of these advanced mass spectrometric and other quantitative proteomic methodologies to laboratory diagnosis. This review focuses on the role of proteomics in the development of new laboratory diagnostics and the implications for routine diagnosis and monitoring of diseases.",
keywords = "Aptamers, Isotope labeling, Mass spectrometer, Peptide arrays, Protein arrays, Protein profiling",
author = "Raghothama Chaerkady and Akhilesh Pandey",
year = "2008",
doi = "10.1146/annurev.pathmechdis.3.121806.151419",
language = "English (US)",
volume = "3",
pages = "485--498",
journal = "Annual Review of Pathology: Mechanisms of Disease",
issn = "1553-4006",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Applications of proteomics to lab diagnosis

AU - Chaerkady, Raghothama

AU - Pandey, Akhilesh

PY - 2008

Y1 - 2008

N2 - Detailed and comprehensive characterization of proteins is a major goal of proteomics. This goal has become more realistic today with the latest high-resolution mass spectrometers capable of faster sequencing in a high-throughput fashion and with the emergence of new techniques such as protein and peptide microarrays. A promising area for discovery is the application of these advanced mass spectrometric and other quantitative proteomic methodologies to laboratory diagnosis. This review focuses on the role of proteomics in the development of new laboratory diagnostics and the implications for routine diagnosis and monitoring of diseases.

AB - Detailed and comprehensive characterization of proteins is a major goal of proteomics. This goal has become more realistic today with the latest high-resolution mass spectrometers capable of faster sequencing in a high-throughput fashion and with the emergence of new techniques such as protein and peptide microarrays. A promising area for discovery is the application of these advanced mass spectrometric and other quantitative proteomic methodologies to laboratory diagnosis. This review focuses on the role of proteomics in the development of new laboratory diagnostics and the implications for routine diagnosis and monitoring of diseases.

KW - Aptamers

KW - Isotope labeling

KW - Mass spectrometer

KW - Peptide arrays

KW - Protein arrays

KW - Protein profiling

UR - http://www.scopus.com/inward/record.url?scp=41749116116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41749116116&partnerID=8YFLogxK

U2 - 10.1146/annurev.pathmechdis.3.121806.151419

DO - 10.1146/annurev.pathmechdis.3.121806.151419

M3 - Article

C2 - 18039142

AN - SCOPUS:41749116116

VL - 3

SP - 485

EP - 498

JO - Annual Review of Pathology: Mechanisms of Disease

JF - Annual Review of Pathology: Mechanisms of Disease

SN - 1553-4006

ER -