Abstract
The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease specific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ect oder mtissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/ drug discovery, gene therapy and cell replacement therapy.
Original language | English (US) |
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Pages (from-to) | 796-805 |
Number of pages | 10 |
Journal | International Journal of Biological Sciences |
Volume | 6 |
Issue number | 7 |
DOIs | |
State | Published - 2010 |
Externally published | Yes |
Keywords
- Disease modeling
- Drug screening
- Liver disease
- Stem cell
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Applied Microbiology and Biotechnology
- Molecular Biology
- Developmental Biology
- Cell Biology