Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease

Yong Soon Chun, Pooja Chaudhari, Yoon Young Jang

Research output: Contribution to journalReview articlepeer-review

Abstract

The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease specific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ect oder mtissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/ drug discovery, gene therapy and cell replacement therapy.

Original languageEnglish (US)
Pages (from-to)796-805
Number of pages10
JournalInternational Journal of Biological Sciences
Volume6
Issue number7
DOIs
StatePublished - 2010

Keywords

  • Disease modeling
  • Drug screening
  • Liver disease
  • Stem cell

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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