Applications of Network Bioinformatics to Cancer Angiogenesis

Corban G. Rivera, Liang Hui Chu, Joel S. Bader, Aleksander S. Popel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Angiogenesis is the formation of new blood vessels from preexisting microvessels. Excessive and insufficient angiogenesis has been associated with many diseases including cancer, age-related macular degeneration, ischemic heart, brain, and skeletal muscle diseases. In this book chapter, we focus on the biological networks associated with angiogenesis in cancer. We review diverse studies on angiogenesis networks, including angiogenic signaling and angiogenic switch networks, global angiogenesis protein-protein interaction networks, crosstalk among angiogenic pathways, and drug networks. This chapter is for readers who are interested in cancer systems biology and bioinformatics, especially in angiogenesis.

Original languageEnglish (US)
Title of host publicationSystems Biology in Cancer Research and Drug Discovery
PublisherSpringer Netherlands
Pages229-244
Number of pages16
Volume9789400748194
ISBN (Electronic)9789400748194
ISBN (Print)9400748183, 9789400748187
DOIs
StatePublished - Aug 1 2012

Keywords

  • Angio-genesis
  • Angiogenesis signaling networks
  • Bioinformatics
  • Network bioinformatics
  • Network biology
  • Protein interaction networks

ASJC Scopus subject areas

  • Medicine(all)

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