Applications of magnetic resonance in model systems

Tumor biology and physiology

Robert J. Gillies, Zaver M Bhujwalla, Jeffrey Evelhoch, Michael Garwood, Michal Neeman, Simon P. Robinson, Christopher H. Sotak, Boudewijn Van Der Sanden

Research output: Contribution to journalArticle

Abstract

A solid tumor presents a unique challenge as a system in which the dynamics of the relationship between vascularization, the physiological environment and metabolism are continually changing with growth and following treatment. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) studies have demonstrated quantifiable linkages between the physiological environment, angiogenesis, vascularization and metabolism of tumors. The dynamics between these parameters continually change with tumor aggressiveness, tumor growth and during therapy and each of these can be monitored longitudinally, quantitatively and non-invasively with MRI and MRS. An important aspect of MRI and MRS studies is that techniques and findings are easily translated between systems. Hence, pre-clinical studies using cultured cells or experimental animals have a high connectivity to potential clinical utility. In the following review, leaders in the field of MR studies of basic tumor physiology using pre-clinical models have contributed individual sections according to their expertise and outlook. The following review is a cogent and timely overview of the current capabilities and state-of-the-art of MRI and MRS as applied to experimental cancers. A companion review deals with the application of MR methods to anticancer therapy.

Original languageEnglish (US)
Pages (from-to)139-151
Number of pages13
JournalNeoplasia
Volume2
Issue number1-2
StatePublished - Jan 2000

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Systems Biology
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Neoplasms
Physiologic Neovascularization
Growth
Cultured Cells
Therapeutics

Keywords

  • Magnetic Resonance imaging (MRI)
  • Magnetic Resonance Spectroscopy (MRS)
  • Tumor Metabolism
  • Tumor Oxygenation
  • Tumor Perfusion
  • Tumor pH

ASJC Scopus subject areas

  • Cancer Research

Cite this

Gillies, R. J., Bhujwalla, Z. M., Evelhoch, J., Garwood, M., Neeman, M., Robinson, S. P., ... Van Der Sanden, B. (2000). Applications of magnetic resonance in model systems: Tumor biology and physiology. Neoplasia, 2(1-2), 139-151.

Applications of magnetic resonance in model systems : Tumor biology and physiology. / Gillies, Robert J.; Bhujwalla, Zaver M; Evelhoch, Jeffrey; Garwood, Michael; Neeman, Michal; Robinson, Simon P.; Sotak, Christopher H.; Van Der Sanden, Boudewijn.

In: Neoplasia, Vol. 2, No. 1-2, 01.2000, p. 139-151.

Research output: Contribution to journalArticle

Gillies, RJ, Bhujwalla, ZM, Evelhoch, J, Garwood, M, Neeman, M, Robinson, SP, Sotak, CH & Van Der Sanden, B 2000, 'Applications of magnetic resonance in model systems: Tumor biology and physiology', Neoplasia, vol. 2, no. 1-2, pp. 139-151.
Gillies RJ, Bhujwalla ZM, Evelhoch J, Garwood M, Neeman M, Robinson SP et al. Applications of magnetic resonance in model systems: Tumor biology and physiology. Neoplasia. 2000 Jan;2(1-2):139-151.
Gillies, Robert J. ; Bhujwalla, Zaver M ; Evelhoch, Jeffrey ; Garwood, Michael ; Neeman, Michal ; Robinson, Simon P. ; Sotak, Christopher H. ; Van Der Sanden, Boudewijn. / Applications of magnetic resonance in model systems : Tumor biology and physiology. In: Neoplasia. 2000 ; Vol. 2, No. 1-2. pp. 139-151.
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