APPLICATIONS OF LASER DESORPTION MASS SPECTROMETRY.

Robert J. Cotter, Jean Claude Tabet, Richard van Breemen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The laser desorption technique can be used for the mass spectral analysis of nonvolatile/thermally labile compounds such as peptides, oligosaccharides, glycolipids, etc. In our laboratory a laser desorption time-of-flight mass spectrometer has been used for structural confirmation of several glucuronic acid conjugates, synthesized by an immobilized-enzyme mediated technique. Laser desorption spectra of several small peptides produce both C-terminal and N-terminal fragments. The molecular ions are formed by cationization (alkali ion attachment) and the alakali ion is generally found on the C-terminal fragments, suggesting a ionization/fragmentation scheme similar to that observed by chemical ionization.

Original languageEnglish (US)
Title of host publicationAnnual Conference on Mass Spectrometry and Allied Topics
EditorsRobert E. Finnigan
PublisherAmerican Soc for Mass Spectrometry
Pages681-682
Number of pages2
Publication statusPublished - 1984

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Cotter, R. J., Tabet, J. C., & van Breemen, R. (1984). APPLICATIONS OF LASER DESORPTION MASS SPECTROMETRY. In R. E. Finnigan (Ed.), Annual Conference on Mass Spectrometry and Allied Topics (pp. 681-682). American Soc for Mass Spectrometry.