Abstract
Human induced pluripotent stem cells (iPSCs) are potential sources of hepatocytes for drug development and cell therapy. In vitro differentiation of iPSCs into hepatic cells has been achieved and improved during the last several years. More recently the in vivo functionality of human iPSC-derived hepatic cells at various differentiation stages has also been demonstrated. In this chapter, we describe the recent advance in human iPSC generation and hepatic differentiation technologies, the in vitro and in vivo activities of human iPSC derived hepatocytes, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening, drug discovery, gene therapy and cell replacement therapy.
| Original language | English (US) |
|---|---|
| Title of host publication | Stem Cells and Cancer Stem Cells, Volume 3 |
| Subtitle of host publication | Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3 |
| Publisher | Springer Netherlands |
| Pages | 213-220 |
| Number of pages | 8 |
| ISBN (Electronic) | 9789400724150 |
| ISBN (Print) | 9789400724143 |
| DOIs | |
| State | Published - Jan 1 2012 |
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Keywords
- Cell replacement therapy
- Disease modeling
- Hepatocytes
- iPSCs
- Liver
- Pluripotent
ASJC Scopus subject areas
- Medicine(all)
Cite this
Applications of human induced pluripotent stem cell derived hepatocytes. / Liu, Hua; Chaudhari, Pooja; Choi, Su Mi; Jang, Yoon Young.
Stem Cells and Cancer Stem Cells, Volume 3: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3. Springer Netherlands, 2012. p. 213-220.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Applications of human induced pluripotent stem cell derived hepatocytes
AU - Liu, Hua
AU - Chaudhari, Pooja
AU - Choi, Su Mi
AU - Jang, Yoon Young
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Human induced pluripotent stem cells (iPSCs) are potential sources of hepatocytes for drug development and cell therapy. In vitro differentiation of iPSCs into hepatic cells has been achieved and improved during the last several years. More recently the in vivo functionality of human iPSC-derived hepatic cells at various differentiation stages has also been demonstrated. In this chapter, we describe the recent advance in human iPSC generation and hepatic differentiation technologies, the in vitro and in vivo activities of human iPSC derived hepatocytes, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening, drug discovery, gene therapy and cell replacement therapy.
AB - Human induced pluripotent stem cells (iPSCs) are potential sources of hepatocytes for drug development and cell therapy. In vitro differentiation of iPSCs into hepatic cells has been achieved and improved during the last several years. More recently the in vivo functionality of human iPSC-derived hepatic cells at various differentiation stages has also been demonstrated. In this chapter, we describe the recent advance in human iPSC generation and hepatic differentiation technologies, the in vitro and in vivo activities of human iPSC derived hepatocytes, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening, drug discovery, gene therapy and cell replacement therapy.
KW - Cell replacement therapy
KW - Disease modeling
KW - Hepatocytes
KW - iPSCs
KW - Liver
KW - Pluripotent
UR - http://www.scopus.com/inward/record.url?scp=85027743542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027743542&partnerID=8YFLogxK
U2 - 10.1007/978-94-007-2415-0_21
DO - 10.1007/978-94-007-2415-0_21
M3 - Chapter
AN - SCOPUS:85027743542
SN - 9789400724143
SP - 213
EP - 220
BT - Stem Cells and Cancer Stem Cells, Volume 3
PB - Springer Netherlands
ER -