Applications of human induced pluripotent stem cell derived hepatocytes

Hua Liu, Pooja Chaudhari, Su Mi Choi, Yoon Young Jang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human induced pluripotent stem cells (iPSCs) are potential sources of hepatocytes for drug development and cell therapy. In vitro differentiation of iPSCs into hepatic cells has been achieved and improved during the last several years. More recently the in vivo functionality of human iPSC-derived hepatic cells at various differentiation stages has also been demonstrated. In this chapter, we describe the recent advance in human iPSC generation and hepatic differentiation technologies, the in vitro and in vivo activities of human iPSC derived hepatocytes, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening, drug discovery, gene therapy and cell replacement therapy.

Original languageEnglish (US)
Title of host publicationStem Cells and Cancer Stem Cells, Volume 3
Subtitle of host publicationStem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3
PublisherSpringer Netherlands
Pages213-220
Number of pages8
ISBN (Electronic)9789400724150
ISBN (Print)9789400724143
DOIs
StatePublished - Jan 1 2012

Fingerprint

Induced Pluripotent Stem Cells
Hepatocytes
Cell- and Tissue-Based Therapy
Preclinical Drug Evaluations
Drug Discovery
Drug-Related Side Effects and Adverse Reactions
Genetic Therapy
Technology
Drug Therapy
Liver

Keywords

  • Cell replacement therapy
  • Disease modeling
  • Hepatocytes
  • iPSCs
  • Liver
  • Pluripotent

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liu, H., Chaudhari, P., Choi, S. M., & Jang, Y. Y. (2012). Applications of human induced pluripotent stem cell derived hepatocytes. In Stem Cells and Cancer Stem Cells, Volume 3: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3 (pp. 213-220). Springer Netherlands. https://doi.org/10.1007/978-94-007-2415-0_21

Applications of human induced pluripotent stem cell derived hepatocytes. / Liu, Hua; Chaudhari, Pooja; Choi, Su Mi; Jang, Yoon Young.

Stem Cells and Cancer Stem Cells, Volume 3: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3. Springer Netherlands, 2012. p. 213-220.

Research output: Chapter in Book/Report/Conference proceedingChapter

Liu, H, Chaudhari, P, Choi, SM & Jang, YY 2012, Applications of human induced pluripotent stem cell derived hepatocytes. in Stem Cells and Cancer Stem Cells, Volume 3: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3. Springer Netherlands, pp. 213-220. https://doi.org/10.1007/978-94-007-2415-0_21
Liu H, Chaudhari P, Choi SM, Jang YY. Applications of human induced pluripotent stem cell derived hepatocytes. In Stem Cells and Cancer Stem Cells, Volume 3: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3. Springer Netherlands. 2012. p. 213-220 https://doi.org/10.1007/978-94-007-2415-0_21
Liu, Hua ; Chaudhari, Pooja ; Choi, Su Mi ; Jang, Yoon Young. / Applications of human induced pluripotent stem cell derived hepatocytes. Stem Cells and Cancer Stem Cells, Volume 3: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3. Springer Netherlands, 2012. pp. 213-220
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