Applications of human induced pluripotent stem cell derived hepatocytes

Hua Liu, Pooja Chaudhari, Su Mi Choi, Yoon Young Jang

Research output: Chapter in Book/Report/Conference proceedingChapter


Human induced pluripotent stem cells (iPSCs) are potential sources of hepatocytes for drug development and cell therapy. In vitro differentiation of iPSCs into hepatic cells has been achieved and improved during the last several years. More recently the in vivo functionality of human iPSC-derived hepatic cells at various differentiation stages has also been demonstrated. In this chapter, we describe the recent advance in human iPSC generation and hepatic differentiation technologies, the in vitro and in vivo activities of human iPSC derived hepatocytes, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening, drug discovery, gene therapy and cell replacement therapy.

Original languageEnglish (US)
Title of host publicationStem Cells and Cancer Stem Cells, Volume 3
Subtitle of host publicationStem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3
PublisherSpringer Netherlands
Number of pages8
ISBN (Electronic)9789400724150
ISBN (Print)9789400724143
StatePublished - Jan 1 2012


  • Cell replacement therapy
  • Disease modeling
  • Hepatocytes
  • iPSCs
  • Liver
  • Pluripotent

ASJC Scopus subject areas

  • Medicine(all)


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