Applications of gene array technology to prostate cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer development and progression represent a continuum of biological behavior driven by altered patterns of gene expression. Characterizing the critical gene targets associated with tumor subtypes or different points along the continuum has become the goal of molecular taxonomy of tumors. Molecular classification includes identification of stages or risk factors in the carcinogenic process, genetic signatures that confer the malignant phenotype to provide a biomarker for early detection or diagnosis, prediction of prognosis and response to specific therapies, and identification of fundamental mechanisms that can be targeted for prevention or treatment. Until recently, these studies were done using a candidate gene approach, wherein genes of interest were investigated one at a time. However, cancer phenotypes involve multiple genetic alterations, and not every case with the same phenotype will exhibit the same set of perturbed genes. Consequently, classification of the determinants of biological behavior may require the ability to evaluate patterns of synchronized genetic events.

Original languageEnglish (US)
Title of host publicationProstate Cancer
Subtitle of host publicationPrinciples and Practice
PublisherCRC Press
Pages43-51
Number of pages9
ISBN (Electronic)9780203624326
ISBN (Print)9781841844589
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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