Applications of display technology protein analysis

M. Li

Research output: Contribution to journalReview article

Abstract

Display technology refers to a collection of methods for creating libraries of modularly coded biomolecules that can be screened for desired properties. It has become a routine tool for enriching molecular diversity and producing novel types of proteins. The combination of an ever-increasing variety of libraries of modularly coded protein complexes with the development of innovative approaches to select a wide array of desired properties has facilitated large-scale analyses of protein-protein/protein-substrate interactions, rapid isolation of antibodies (or antibody mimetics) without immunization, and function-based protein analysis. Several practical and theoretical challenges remain to be addressed before display technology can be readily applied to proteomic studies.

Original languageEnglish (US)
Pages (from-to)1251-1256
Number of pages6
JournalNature biotechnology
Volume18
Issue number12
DOIs
StatePublished - Dec 23 2000

Keywords

  • Functional genomics
  • Phage display
  • Protein-protein interactions
  • Proteomic technologies

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

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