TY - JOUR
T1 - Application of three-class ROC analysis to task-based image quality assessment of simultaneous dual-isotope myocardial perfusion SPECT (MPS)
AU - He, Xin
AU - Song, Xiyun
AU - Frey, Eric C.
N1 - Funding Information:
Manuscript received April 14, 2008; revised June 12, 2008. Current version published October 24, 2008. This work was supported by the National Institutes of Health under Grant K99-EB007620, R01-EB000288 and Grant R01-HL068575. The content of this work is solely the responsibility of the authors and does not necessarily represent the official view of the National Institutes of Health or its various institutes. Asterisk indicates corresponding author. *X. He is with the Department of Radiology, Johns Hopkins School of Medicine, 601 N. Caroline Street, Baltimore, MD 21287 USA (e-mail: xinhe@jhmi.edu).
PY - 2008/11
Y1 - 2008/11
N2 - The diagnosis of cardiac disease using dual-isotope myocardial perfusion SPECT (MPS) is based on the defect status in both stress and rest images, and can be modeled as a three-class task of classifying patients as having no, reversible, or fixed perfusion defects. Simultaneous acquisition protocols for dual-isotope MPS imaging have gained much interest due to their advantages including perfect registration of the 201T1 and 99mTc images in space and time, increased patient comfort, and higher clinical throughput. As a result of simultaneous acquisition, however, crosstalk contamination, where photons emitted by one isotope contribute to the image of the other isotope, degrades image quality. Minimizing the crosstalk is important in obtaining the best possible image quality. One way to minimize the crosstalk is to optimize the injected activity of the two isotopes by considering the three-class nature of the diagnostic problem. To effectively do so, we have previously developed a three-class receiver operating characteristic (ROC) analysis methodology that extends and unifies the decision theoretic, linear discriminant analysis, and psychophysical foundations of binary ROC analysis in a three-class paradigm. In this work, we applied the proposed three-class ROC methodology to the assessment of the image quality of simultaneous dual-isotope MPS imaging techniques and the determination of the optimal injected activity combination. In addition to this application, the rapid development of diagnostic imaging techniques has produced an increasing number of clinical diagnostic tasks that involve not only disease detection, but also disease characterization and are thus multiclass tasks. This paper provides a practical example of the application of the proposed three-class ROC analysis methodology to medical problems.
AB - The diagnosis of cardiac disease using dual-isotope myocardial perfusion SPECT (MPS) is based on the defect status in both stress and rest images, and can be modeled as a three-class task of classifying patients as having no, reversible, or fixed perfusion defects. Simultaneous acquisition protocols for dual-isotope MPS imaging have gained much interest due to their advantages including perfect registration of the 201T1 and 99mTc images in space and time, increased patient comfort, and higher clinical throughput. As a result of simultaneous acquisition, however, crosstalk contamination, where photons emitted by one isotope contribute to the image of the other isotope, degrades image quality. Minimizing the crosstalk is important in obtaining the best possible image quality. One way to minimize the crosstalk is to optimize the injected activity of the two isotopes by considering the three-class nature of the diagnostic problem. To effectively do so, we have previously developed a three-class receiver operating characteristic (ROC) analysis methodology that extends and unifies the decision theoretic, linear discriminant analysis, and psychophysical foundations of binary ROC analysis in a three-class paradigm. In this work, we applied the proposed three-class ROC methodology to the assessment of the image quality of simultaneous dual-isotope MPS imaging techniques and the determination of the optimal injected activity combination. In addition to this application, the rapid development of diagnostic imaging techniques has produced an increasing number of clinical diagnostic tasks that involve not only disease detection, but also disease characterization and are thus multiclass tasks. This paper provides a practical example of the application of the proposed three-class ROC analysis methodology to medical problems.
KW - Dual-isotope myocardial perfusion SPECT (MPS)
KW - Simultaneous acquisition
KW - Task-based image quality assessment
KW - Three-class hotelling observer
KW - Three-class receiver operating characteristic (ROC) analysis
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U2 - 10.1109/TMI.2008.928921
DO - 10.1109/TMI.2008.928921
M3 - Article
C2 - 18955172
AN - SCOPUS:54949103513
SN - 0278-0062
VL - 27
SP - 1556
EP - 1567
JO - IEEE transactions on medical imaging
JF - IEEE transactions on medical imaging
IS - 11
M1 - 4580127
ER -