Application of the laguerre deconvolution method for time-resolved fluorescence spectroscopy to the characterization of atherosclerotic plaques

J. A. Jo; Q. Fang; T. Papaioannou; J. H. Qiao; M. C. Fishbein; B. Beseth; A. H. Dorafshar; T. Reil; D. Baker; J. Freischlag; L. Marcu

doi:10.1109/iembs.2005.1616003

Application of the laguerre deconvolution method for time-resolved fluorescence spectroscopy to the characterization of atherosclerotic plaques

J. A. Jo, Q. Fang, T. Papaioannou, J. H. Qiao, M. C. Fishbein, B. Beseth, A. H. Dorafshar, T. Reil, D. Baker, J. Freischlag, L. Marcu

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

This study investigates the ability of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) to detect inflammation in atherosclerotic lesion, a key feature of plaque vulnerability. A total of 348 TR-LIFS measurements were taken from carotid plaques of 30 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified as Early, Fibrotic/Calcified or Inflamed lesions. A stepwise linear discriminant analysis algorithm was developed using spectral and TR features (normalized intensity values and Laguerre expansion coefficients at discrete emission wavelengths, respectively). Features from only three emission wavelengths (390, 450 and 500 nm) were used in the classifier. The Inflamed lesions were discriminated with sensitivity > 80% and specificity >90 %, when the Laguerre expansion coefficients were included in the feature space. These results indicate that TR-LIFS information derived from the Laguerre expansion coefficients at few selected emission wavelengths can discriminate inflammation in atherosclerotic plaques. We believe that TR-LIFS derived Laguerre expansion coefficients can provide a valuable additional dimension for the detection of vulnerable plaques.

Original language	English (US)
Title of host publication	Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	6559-6562
Number of pages	4
ISBN (Print)	0780387406, 9780780387409
DOIs	https://doi.org/10.1109/iembs.2005.1616003
State	Published - 2005
Event	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China Duration: Sep 1 2005 → Sep 4 2005

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	7 VOLS
ISSN (Print)	0589-1019

Other

Other	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Country/Territory	China
City	Shanghai
Period	9/1/05 → 9/4/05

Keywords

Atherosclerosis
Laguerre expansion technique
Time-resolved fluorescence spectroscopy

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Access to Document

10.1109/iembs.2005.1616003

Cite this

Jo, J. A., Fang, Q., Papaioannou, T., Qiao, J. H., Fishbein, M. C., Beseth, B., Dorafshar, A. H., Reil, T., Baker, D., Freischlag, J., & Marcu, L. (2005). Application of the laguerre deconvolution method for time-resolved fluorescence spectroscopy to the characterization of atherosclerotic plaques. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 6559-6562). Article 1616003 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/iembs.2005.1616003

Application of the laguerre deconvolution method for time-resolved fluorescence spectroscopy to the characterization of atherosclerotic plaques. / Jo, J. A.; Fang, Q.; Papaioannou, T. et al.
Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. Institute of Electrical and Electronics Engineers Inc., 2005. p. 6559-6562 1616003 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Jo, JA, Fang, Q, Papaioannou, T, Qiao, JH, Fishbein, MC, Beseth, B, Dorafshar, AH, Reil, T, Baker, D, Freischlag, J & Marcu, L 2005, Application of the laguerre deconvolution method for time-resolved fluorescence spectroscopy to the characterization of atherosclerotic plaques. in Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005., 1616003, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 7 VOLS, Institute of Electrical and Electronics Engineers Inc., pp. 6559-6562, 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005, Shanghai, China, 9/1/05. https://doi.org/10.1109/iembs.2005.1616003

Jo JA, Fang Q, Papaioannou T, Qiao JH, Fishbein MC, Beseth B et al. Application of the laguerre deconvolution method for time-resolved fluorescence spectroscopy to the characterization of atherosclerotic plaques. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. Institute of Electrical and Electronics Engineers Inc. 2005. p. 6559-6562. 1616003. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). doi: 10.1109/iembs.2005.1616003

Jo, J. A. ; Fang, Q. ; Papaioannou, T. et al. / Application of the laguerre deconvolution method for time-resolved fluorescence spectroscopy to the characterization of atherosclerotic plaques. Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. Institute of Electrical and Electronics Engineers Inc., 2005. pp. 6559-6562 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

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abstract = "This study investigates the ability of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) to detect inflammation in atherosclerotic lesion, a key feature of plaque vulnerability. A total of 348 TR-LIFS measurements were taken from carotid plaques of 30 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified as Early, Fibrotic/Calcified or Inflamed lesions. A stepwise linear discriminant analysis algorithm was developed using spectral and TR features (normalized intensity values and Laguerre expansion coefficients at discrete emission wavelengths, respectively). Features from only three emission wavelengths (390, 450 and 500 nm) were used in the classifier. The Inflamed lesions were discriminated with sensitivity > 80% and specificity >90 %, when the Laguerre expansion coefficients were included in the feature space. These results indicate that TR-LIFS information derived from the Laguerre expansion coefficients at few selected emission wavelengths can discriminate inflammation in atherosclerotic plaques. We believe that TR-LIFS derived Laguerre expansion coefficients can provide a valuable additional dimension for the detection of vulnerable plaques.",

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AU - Fishbein, M. C.

AU - Beseth, B.

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AB - This study investigates the ability of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) to detect inflammation in atherosclerotic lesion, a key feature of plaque vulnerability. A total of 348 TR-LIFS measurements were taken from carotid plaques of 30 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified as Early, Fibrotic/Calcified or Inflamed lesions. A stepwise linear discriminant analysis algorithm was developed using spectral and TR features (normalized intensity values and Laguerre expansion coefficients at discrete emission wavelengths, respectively). Features from only three emission wavelengths (390, 450 and 500 nm) were used in the classifier. The Inflamed lesions were discriminated with sensitivity > 80% and specificity >90 %, when the Laguerre expansion coefficients were included in the feature space. These results indicate that TR-LIFS information derived from the Laguerre expansion coefficients at few selected emission wavelengths can discriminate inflammation in atherosclerotic plaques. We believe that TR-LIFS derived Laguerre expansion coefficients can provide a valuable additional dimension for the detection of vulnerable plaques.

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Application of the laguerre deconvolution method for time-resolved fluorescence spectroscopy to the characterization of atherosclerotic plaques

Abstract

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