Application of reconstruction-based scatter compensation to thallium-201 SPECT: Implementations for reduced reconstructed image noise

D. J. Kadrmas; E. C. Frey; B. M.W. Tsui

doi:10.1109/42.712122

Application of reconstruction-based scatter compensation to thallium-201 SPECT: Implementations for reduced reconstructed image noise

D. J. Kadrmas, E. C. Frey, B. M.W. Tsui

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Scatter compensation in Tl-201 single photon emission computed tomography (SPECT) presents an interesting challenge because of the multiple emission energies and relatively large proportion of scattered photons. In this paper, we present a simulation study investigating reconstructed image noise levels arising from various implementations of iterative reconstructionbased scatter compensation (RBSC) in Tl-201 SPECT. A twostage analysis was used to study single and multiple energy window implementations of reconstruction-based scatter compensation, and RBSC was compared to the upper limits on performance for other approaches to handling scatter. In the first stage, singular value decomposition of the system transfer matrix was used to analyze noise levels in a manner independent of the choice of reconstruction algorithm, providing results valid across a wide range of regularizations. In the second stage, the data were reconstructed using maximum-likelihood expectationmaximization, and the noise properties of the resultant images were analyzed. The best RBSC performance was obtained using multiple energy windows, one for each emission photopeak, and RBSC outperformed the upper limit on subtraction-based compensation methods. Implementing RBSC with the correct choice of energy window acquisition scheme is a promising method for performing scatter compensation for Tl-201 SPECT.

Original language	English (US)
Pages (from-to)	325-333
Number of pages	9
Journal	IEEE transactions on medical imaging
Volume	17
Issue number	3
DOIs	https://doi.org/10.1109/42.712122
State	Published - 1998
Externally published	Yes

Keywords

Iterative reconstruction
SPECT
SVD
Scatter compensation

ASJC Scopus subject areas

Software
Radiological and Ultrasound Technology
Computer Science Applications
Electrical and Electronic Engineering

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10.1109/42.712122

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title = "Application of reconstruction-based scatter compensation to thallium-201 SPECT: Implementations for reduced reconstructed image noise",

abstract = "Scatter compensation in Tl-201 single photon emission computed tomography (SPECT) presents an interesting challenge because of the multiple emission energies and relatively large proportion of scattered photons. In this paper, we present a simulation study investigating reconstructed image noise levels arising from various implementations of iterative reconstructionbased scatter compensation (RBSC) in Tl-201 SPECT. A twostage analysis was used to study single and multiple energy window implementations of reconstruction-based scatter compensation, and RBSC was compared to the upper limits on performance for other approaches to handling scatter. In the first stage, singular value decomposition of the system transfer matrix was used to analyze noise levels in a manner independent of the choice of reconstruction algorithm, providing results valid across a wide range of regularizations. In the second stage, the data were reconstructed using maximum-likelihood expectationmaximization, and the noise properties of the resultant images were analyzed. The best RBSC performance was obtained using multiple energy windows, one for each emission photopeak, and RBSC outperformed the upper limit on subtraction-based compensation methods. Implementing RBSC with the correct choice of energy window acquisition scheme is a promising method for performing scatter compensation for Tl-201 SPECT.",

keywords = "Iterative reconstruction, SPECT, SVD, Scatter compensation",

author = "Kadrmas, {D. J.} and Frey, {E. C.} and Tsui, {B. M.W.}",

note = "Funding Information: Manuscript received July 21, 1997; revised March 17, 1998. This work was supported by the National Cancer Institute (NCI) under Grant R29-CA63465, and by grants from Cray Research, Inc. and the North Carolina Supercomputer Center. The Associate Editor responsible for coordinating the review of this paper and recommending its publication was G. T. Gullberg. Asterisk indicates corresponding author. *D. J. Kadrmas was with the Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA. He is now with the Department of Radiology, University of Utah, Medical Imaging Research Laboratory, CAMT, 729 Arapeen Dr., Salt Lake City, UT 84108-1218 USA (e-mail: kadrmas@mirl.med.utah.edu).",

year = "1998",

doi = "10.1109/42.712122",

language = "English (US)",

volume = "17",

pages = "325--333",

journal = "IEEE transactions on medical imaging",

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TY - JOUR

T1 - Application of reconstruction-based scatter compensation to thallium-201 SPECT

T2 - Implementations for reduced reconstructed image noise

AU - Kadrmas, D. J.

AU - Frey, E. C.

AU - Tsui, B. M.W.

N1 - Funding Information: Manuscript received July 21, 1997; revised March 17, 1998. This work was supported by the National Cancer Institute (NCI) under Grant R29-CA63465, and by grants from Cray Research, Inc. and the North Carolina Supercomputer Center. The Associate Editor responsible for coordinating the review of this paper and recommending its publication was G. T. Gullberg. Asterisk indicates corresponding author. *D. J. Kadrmas was with the Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA. He is now with the Department of Radiology, University of Utah, Medical Imaging Research Laboratory, CAMT, 729 Arapeen Dr., Salt Lake City, UT 84108-1218 USA (e-mail: kadrmas@mirl.med.utah.edu).

PY - 1998

Y1 - 1998

N2 - Scatter compensation in Tl-201 single photon emission computed tomography (SPECT) presents an interesting challenge because of the multiple emission energies and relatively large proportion of scattered photons. In this paper, we present a simulation study investigating reconstructed image noise levels arising from various implementations of iterative reconstructionbased scatter compensation (RBSC) in Tl-201 SPECT. A twostage analysis was used to study single and multiple energy window implementations of reconstruction-based scatter compensation, and RBSC was compared to the upper limits on performance for other approaches to handling scatter. In the first stage, singular value decomposition of the system transfer matrix was used to analyze noise levels in a manner independent of the choice of reconstruction algorithm, providing results valid across a wide range of regularizations. In the second stage, the data were reconstructed using maximum-likelihood expectationmaximization, and the noise properties of the resultant images were analyzed. The best RBSC performance was obtained using multiple energy windows, one for each emission photopeak, and RBSC outperformed the upper limit on subtraction-based compensation methods. Implementing RBSC with the correct choice of energy window acquisition scheme is a promising method for performing scatter compensation for Tl-201 SPECT.

AB - Scatter compensation in Tl-201 single photon emission computed tomography (SPECT) presents an interesting challenge because of the multiple emission energies and relatively large proportion of scattered photons. In this paper, we present a simulation study investigating reconstructed image noise levels arising from various implementations of iterative reconstructionbased scatter compensation (RBSC) in Tl-201 SPECT. A twostage analysis was used to study single and multiple energy window implementations of reconstruction-based scatter compensation, and RBSC was compared to the upper limits on performance for other approaches to handling scatter. In the first stage, singular value decomposition of the system transfer matrix was used to analyze noise levels in a manner independent of the choice of reconstruction algorithm, providing results valid across a wide range of regularizations. In the second stage, the data were reconstructed using maximum-likelihood expectationmaximization, and the noise properties of the resultant images were analyzed. The best RBSC performance was obtained using multiple energy windows, one for each emission photopeak, and RBSC outperformed the upper limit on subtraction-based compensation methods. Implementing RBSC with the correct choice of energy window acquisition scheme is a promising method for performing scatter compensation for Tl-201 SPECT.

KW - Iterative reconstruction

KW - SPECT

KW - SVD

KW - Scatter compensation

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JO - IEEE transactions on medical imaging

JF - IEEE transactions on medical imaging

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ER -

Application of reconstruction-based scatter compensation to thallium-201 SPECT: Implementations for reduced reconstructed image noise

Abstract

Keywords

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