Application of reconstruction-based scatter compensation to T1-201 SPECT

D. J. Kadrmas, E. C. Frey, B. M.W. Tsui

Research output: Contribution to conferencePaperpeer-review


Scatter compensation in Tl-201 SPECT presents an interesting challenge because of the multiple emission energies and relatively large proportion of scattered photons. Reconstruction-based scatter compensation (RBSC), in which the scatter response function is modeled during the reconstruction, can improve quantitative accuracy and contrast while maintaining or even reducing image noise levels. In this work we investigate methods of applying RBSC to Tl-201 SPECT and study the noise levels resulting from each method. We have applied RBSC to a simulated phantom experiment using a variety of single and multiple energy window schemes. The RBSC methods were also compared with other methods of handling scatter. Singular value decomposition (SVD) of the system transfer matrix was used to analyze the noise levels of each method in a regularization-independent manner. Results indicate that inclusion of higher energy gamma peak data leads to reduce noise over using only x-ray emission data. In addition, using a different window for each emission energy gives better performance than acquiring into a single wide energy window. Non-photopeak window data can also be included to reduce image noise. These results are supported by analysis of iteratively reconstructed MLEM images.

Original languageEnglish (US)
Number of pages5
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 IEEE Nuclear Science Symposium. Part 1 (of 3) - Anaheim, CA, USA
Duration: Nov 2 1996Nov 9 1996


OtherProceedings of the 1996 IEEE Nuclear Science Symposium. Part 1 (of 3)
CityAnaheim, CA, USA

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Application of reconstruction-based scatter compensation to T1-201 SPECT'. Together they form a unique fingerprint.

Cite this