Ultrastructural morphometry makes it possible to quantitate the pathomorphological changes in cells and cell organelles. Morphometric data gathered on cellular reactions to various cell injuries suggest that the cell has only a limited repertoire of response to a wide variety of injuries. As a first step in documenting this hypothesis, a self-consistent model of organelle pathology has been constructed in terms of the general pathology of growth disorders. This model employs the nullity approach, introduced by Quine. A computer algorithm for extracting an exhaustive, pathomorphologic description from a standardized panel of morphometric measurements is presented, and the exhaustiveness of this algorithm is proved mathematically. Over 70 panels of morphometric data from the literature have been successfully analyzed using this model of organelle pathology.
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)