Application of Quine's nullities to a quantitative organelle pathology

G. William Moore, U. N. Riede, W. Sandritter

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Ultrastructural morphometry makes it possible to quantitate the pathomorphological changes in cells and cell organelles. Morphometric data gathered on cellular reactions to various cell injuries suggest that the cell has only a limited repertoire of response to a wide variety of injuries. As a first step in documenting this hypothesis, a self-consistent model of organelle pathology has been constructed in terms of the general pathology of growth disorders. This model employs the nullity approach, introduced by Quine. A computer algorithm for extracting an exhaustive, pathomorphologic description from a standardized panel of morphometric measurements is presented, and the exhaustiveness of this algorithm is proved mathematically. Over 70 panels of morphometric data from the literature have been successfully analyzed using this model of organelle pathology.

Original languageEnglish (US)
Pages (from-to)633-651
Number of pages19
JournalJournal of Theoretical Biology
Issue number4
StatePublished - Apr 21 1977
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)


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