Application of Phosphorus‐31 Nuclear Magnetic Resonance Spectrosocopy for the Study of Human Diabetic Cataractogenesis

Andy Hay, James Aguayo, Walter Stark, Chung‐Ho ‐H Chen, Ugur Camli, Lou‐Sing ‐S Kan

Research output: Contribution to journalArticlepeer-review

Abstract

Intact human Senses incubated at 5.5 mM (normal) and 35.5 mM glucose were examined by phosphorus‐31 nuclear magnetic resonance (31P NMR) spectroscopy. Lense in 35.5 mM glucose showed an altered metabolic steady‐state characterized by a lowered adenosine triphosphate/inorganic orthophosphate ratio. 31P NMR spectroscopy can be used to measure metabolic changes in the lens. This model offers an important means to study dynamic metabolism in the human lens in the setting of diabetic cataractogenesis.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalJournal of the Chinese Chemical Society
Volume36
Issue number2
DOIs
StatePublished - 1989

Keywords

  • P NMR
  • Cataractogenesis
  • Diabetics
  • Human lenses

ASJC Scopus subject areas

  • Chemistry(all)

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