Application of odds ratio regression models for assessing familial aggregation from case-control studies

K. Y. Liang, T. H. Beaty, B. H. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

A regression model for estimating covariate effects on odds ratios to test for familial aggregation of common disease in first-degree relatives of cases and controls is presented and illustrated by using family data from a study of chronic obstructive pulmonary disease. These estimators are in essence an extension of the Mantel-Haenszel estimator of odds ratio but do not require the assumption of independence among relatives. A robust test statistic for possible effects of covariates such as the matching variables for cases and controls on odds ratio is also presented. In data on 156 adult first-degree relatives of 28 cases with demonstrated airway obstruction and 28 controls matched for age, sex, race, and hospital status, there appeared to be a difference in the odds ratio among families of black and white case-control pairs. However, the small sample size available prevents conclusive interpretation of this observation.

Original languageEnglish (US)
Pages (from-to)678-683
Number of pages6
JournalAmerican journal of epidemiology
Volume124
Issue number4
DOIs
StatePublished - Oct 1986

Keywords

  • Chronic obstructive pulmonary disease
  • Regression analysis
  • Risk
  • Statistics

ASJC Scopus subject areas

  • Epidemiology

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