A regression model for estimating covariate effects on odds ratios to test for familial aggregation of common disease in first-degree relatives of cases and controls is presented and illustrated by using family data from a study of chronic obstructive pulmonary disease. These estimators are in essence an extension of the Mantel-Haenszel estimator of odds ratio but do not require the assumption of independence among relatives. A robust test statistic for possible effects of covariates such as the matching variables for cases and controls on odds ratio is also presented. In data on 156 adult first-degree relatives of 28 cases with demonstrated airway obstruction and 28 controls matched for age, sex, race, and hospital status, there appeared to be a difference in the odds ratio among families of black and white case-control pairs. However, the small sample size available prevents conclusive interpretation of this observation.
|Original language||English (US)|
|Number of pages||6|
|Journal||American journal of epidemiology|
|State||Published - Oct 1986|
- Chronic obstructive pulmonary disease
- Regression analysis
ASJC Scopus subject areas