Abstract
A regression model for estimating covariate effects on odds ratios to test for familial aggregation of common disease in first-degree relatives of cases and controls is presented and illustrated by using family data from a study of chronic obstructive pulmonary disease. These estimators are in essence an extension of the Mantel-Haenszel estimator of odds ratio but do not require the assumption of independence among relatives. A robust test statistic for possible effects of covariates such as the matching variables for cases and controls on odds ratio is also presented. In data on 156 adult first-degree relatives of 28 cases with demonstrated airway obstruction and 28 controls matched for age, sex, race, and hospital status, there appeared to be a difference in the odds ratio among families of black and white case-control pairs. However, the small sample size available prevents conclusive interpretation of this observation.
Original language | English (US) |
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Pages (from-to) | 678-683 |
Number of pages | 6 |
Journal | American journal of epidemiology |
Volume | 124 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1986 |
Keywords
- Chronic obstructive pulmonary disease
- Regression analysis
- Risk
- Statistics
ASJC Scopus subject areas
- Epidemiology