Abstract
Background: Most microarray data processing methods negate extreme expression values or alter them so that they do not lie outside the mean level of variation of the system. While microarrays generate a substantial amount of false positive and spurious results, some of the extreme expression values may be valid and could represent true biological findings. Methods: We propose a simple method to screen brain microarray data to detect individual differences across a psychiatric sample set. We demonstrate in two different samples how this method can be applied. Results: This method targets high-throughput technology to psychiatric research on a subject-specific basis. Conclusion: Assessing microarray data for both mean group effects and individual effects can lead to more robust findings in psychiatric genetics.
Original language | English (US) |
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Article number | 29 |
Journal | BMC psychiatry |
Volume | 8 |
DOIs | |
State | Published - Apr 23 2008 |
Externally published | Yes |
ASJC Scopus subject areas
- Psychiatry and Mental health