Application of innate immune molecules for a new class of drugs: Infection, inflammation and beyond

H. J. Kimura, K. Suzuki, M. A. Landek-Salgado, Patrizio P Caturegli, N. Jounai, K. Kobiyama, F. Takeshita

Research output: Contribution to journalArticle

Abstract

The innate immune system plays an important role systemically and locally in infectious and inflammatory diseases. Vaccines, vaccine adjuvants and anti-inflammatory drugs were developed by understanding mechanisms of the innate immune system and causative factors of infection and inflammatory diseases. Pattern-recognition receptors, such as Toll-like receptors, retinoic acid-inducible gene I (RIG-I)-like helicases and nucleotide-binding oligomerization domain (NOD)-like receptors, and their downstream signals have great potential as targets of therapeutics because they are involved in numerous diseases. Furthermore, proteolytic systems such as autophagy and immunoproteasomes play important roles in the innate immune system, making them potential therapeutic targets also. By taking advantage of the immune system, humankind has made a great effort to develop new therapeutic and preventive medicines. Accordingly, we have reported several studies on the development of vaccines and adjuvants based on novel mechanistic strategies. Additionally, we have elucidated the mechanism underlying an interaction between innate immunity and the endocrine system. This review introduces the possible use of innate immune molecules for the development of immunomodulatory drugs and the involvement of the immune system in endocrine metabolic diseases to discuss future applications of innate immune molecules to therapeutics of various inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalEndocrine, Metabolic and Immune Disorders - Drug Targets
Volume11
Issue number1
StatePublished - 2011

Fingerprint

Immune System
Inflammation
Infection
Pharmaceutical Preparations
Vaccines
Endocrine System Diseases
Pattern Recognition Receptors
Preventive Medicine
Endocrine System
Toll-Like Receptors
Metabolic Diseases
Autophagy
Therapeutics
Tretinoin
Innate Immunity
Communicable Diseases
Anti-Inflammatory Agents
Nucleotides
Genes

Keywords

  • Adjuvant
  • dsDNA
  • Innate immunity
  • Thyroid
  • Vaccine

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

Cite this

Kimura, H. J., Suzuki, K., Landek-Salgado, M. A., Caturegli, P. P., Jounai, N., Kobiyama, K., & Takeshita, F. (2011). Application of innate immune molecules for a new class of drugs: Infection, inflammation and beyond. Endocrine, Metabolic and Immune Disorders - Drug Targets, 11(1), 68-75.

Application of innate immune molecules for a new class of drugs : Infection, inflammation and beyond. / Kimura, H. J.; Suzuki, K.; Landek-Salgado, M. A.; Caturegli, Patrizio P; Jounai, N.; Kobiyama, K.; Takeshita, F.

In: Endocrine, Metabolic and Immune Disorders - Drug Targets, Vol. 11, No. 1, 2011, p. 68-75.

Research output: Contribution to journalArticle

Kimura, HJ, Suzuki, K, Landek-Salgado, MA, Caturegli, PP, Jounai, N, Kobiyama, K & Takeshita, F 2011, 'Application of innate immune molecules for a new class of drugs: Infection, inflammation and beyond', Endocrine, Metabolic and Immune Disorders - Drug Targets, vol. 11, no. 1, pp. 68-75.
Kimura, H. J. ; Suzuki, K. ; Landek-Salgado, M. A. ; Caturegli, Patrizio P ; Jounai, N. ; Kobiyama, K. ; Takeshita, F. / Application of innate immune molecules for a new class of drugs : Infection, inflammation and beyond. In: Endocrine, Metabolic and Immune Disorders - Drug Targets. 2011 ; Vol. 11, No. 1. pp. 68-75.
@article{883e0433659d46e0981eaada8bf8166d,
title = "Application of innate immune molecules for a new class of drugs: Infection, inflammation and beyond",
abstract = "The innate immune system plays an important role systemically and locally in infectious and inflammatory diseases. Vaccines, vaccine adjuvants and anti-inflammatory drugs were developed by understanding mechanisms of the innate immune system and causative factors of infection and inflammatory diseases. Pattern-recognition receptors, such as Toll-like receptors, retinoic acid-inducible gene I (RIG-I)-like helicases and nucleotide-binding oligomerization domain (NOD)-like receptors, and their downstream signals have great potential as targets of therapeutics because they are involved in numerous diseases. Furthermore, proteolytic systems such as autophagy and immunoproteasomes play important roles in the innate immune system, making them potential therapeutic targets also. By taking advantage of the immune system, humankind has made a great effort to develop new therapeutic and preventive medicines. Accordingly, we have reported several studies on the development of vaccines and adjuvants based on novel mechanistic strategies. Additionally, we have elucidated the mechanism underlying an interaction between innate immunity and the endocrine system. This review introduces the possible use of innate immune molecules for the development of immunomodulatory drugs and the involvement of the immune system in endocrine metabolic diseases to discuss future applications of innate immune molecules to therapeutics of various inflammatory diseases.",
keywords = "Adjuvant, dsDNA, Innate immunity, Thyroid, Vaccine",
author = "Kimura, {H. J.} and K. Suzuki and Landek-Salgado, {M. A.} and Caturegli, {Patrizio P} and N. Jounai and K. Kobiyama and F. Takeshita",
year = "2011",
language = "English (US)",
volume = "11",
pages = "68--75",
journal = "Endocrine, Metabolic and Immune Disorders - Drug Targets",
issn = "1871-5303",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Application of innate immune molecules for a new class of drugs

T2 - Infection, inflammation and beyond

AU - Kimura, H. J.

AU - Suzuki, K.

AU - Landek-Salgado, M. A.

AU - Caturegli, Patrizio P

AU - Jounai, N.

AU - Kobiyama, K.

AU - Takeshita, F.

PY - 2011

Y1 - 2011

N2 - The innate immune system plays an important role systemically and locally in infectious and inflammatory diseases. Vaccines, vaccine adjuvants and anti-inflammatory drugs were developed by understanding mechanisms of the innate immune system and causative factors of infection and inflammatory diseases. Pattern-recognition receptors, such as Toll-like receptors, retinoic acid-inducible gene I (RIG-I)-like helicases and nucleotide-binding oligomerization domain (NOD)-like receptors, and their downstream signals have great potential as targets of therapeutics because they are involved in numerous diseases. Furthermore, proteolytic systems such as autophagy and immunoproteasomes play important roles in the innate immune system, making them potential therapeutic targets also. By taking advantage of the immune system, humankind has made a great effort to develop new therapeutic and preventive medicines. Accordingly, we have reported several studies on the development of vaccines and adjuvants based on novel mechanistic strategies. Additionally, we have elucidated the mechanism underlying an interaction between innate immunity and the endocrine system. This review introduces the possible use of innate immune molecules for the development of immunomodulatory drugs and the involvement of the immune system in endocrine metabolic diseases to discuss future applications of innate immune molecules to therapeutics of various inflammatory diseases.

AB - The innate immune system plays an important role systemically and locally in infectious and inflammatory diseases. Vaccines, vaccine adjuvants and anti-inflammatory drugs were developed by understanding mechanisms of the innate immune system and causative factors of infection and inflammatory diseases. Pattern-recognition receptors, such as Toll-like receptors, retinoic acid-inducible gene I (RIG-I)-like helicases and nucleotide-binding oligomerization domain (NOD)-like receptors, and their downstream signals have great potential as targets of therapeutics because they are involved in numerous diseases. Furthermore, proteolytic systems such as autophagy and immunoproteasomes play important roles in the innate immune system, making them potential therapeutic targets also. By taking advantage of the immune system, humankind has made a great effort to develop new therapeutic and preventive medicines. Accordingly, we have reported several studies on the development of vaccines and adjuvants based on novel mechanistic strategies. Additionally, we have elucidated the mechanism underlying an interaction between innate immunity and the endocrine system. This review introduces the possible use of innate immune molecules for the development of immunomodulatory drugs and the involvement of the immune system in endocrine metabolic diseases to discuss future applications of innate immune molecules to therapeutics of various inflammatory diseases.

KW - Adjuvant

KW - dsDNA

KW - Innate immunity

KW - Thyroid

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=79952998026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952998026&partnerID=8YFLogxK

M3 - Article

C2 - 21348819

AN - SCOPUS:79952998026

VL - 11

SP - 68

EP - 75

JO - Endocrine, Metabolic and Immune Disorders - Drug Targets

JF - Endocrine, Metabolic and Immune Disorders - Drug Targets

SN - 1871-5303

IS - 1

ER -