Application of Human Leukocyte Antigen-G Expression in the Diagnosis of Human Cancer

Research output: Contribution to journalArticle

Abstract

It has been well known that human leukocyte antigen (HLA)-G molecules are present in a variety of human neoplastic diseases, and the molecule may contribute to the escape of tumor cells from immune surveillance. Besides the studies that aim at elucidating the roles of HLA-G in immune regulation, the researches that focus on potential applications of HLA-G expression in cancer diagnosis represent another perspective in HLA-G research. This review summarizes those recent translational studies of HLA-G expression in the diagnosis of human cancer. Specifically, the promises and challenges for applying HLA-G expression to detect cancer in body fluids, to diagnose different types of human cancer and to predict clinical outcome in cancer patients will be briefly reviewed.

Original languageEnglish (US)
Pages (from-to)272-276
Number of pages5
JournalHuman Immunology
Volume68
Issue number4
DOIs
StatePublished - Apr 1 2007

Keywords

  • detection
  • diagnosis
  • human cancer
  • prognosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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